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. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: Int J Hematol. 2017 May 22;106(1):45–54. doi: 10.1007/s12185-017-2262-9

Fig. 3.

Fig. 3

Two models of the interaction of leukemic cells and their microenvironment.

While leukemic cells can induce changes in HSC niche (a), abnormalities in bone marrow microenvironment have a potential to initiate hematological malignancies (b). It is of note that these two models are not mutually exclusive. They can form a self-reinforcing loop, contributing to the disease progression. KO; knockout, OE; overexpression.