Table 3.

Longitudinal (4-Year) Change in OAI Healthy Reference Cohort Participant Knees with and without MRI-Detected Femorotibial Cartilage Damage ^a .

	Knees without Any Femorotibial Cartilage Damage		Knees with Any Femorotibial Cartilage Damage		P Value
	Mean	SD	Mean	SD
Change score (µm)	1058	277	1216	434	0.049
Thinning score (µ)	−519	302	−664	484	0.10
Thickening score (µ)	539	330	552	402	0.87
FTJ (µm)	20	141	−11	197	0.40
MFTC (µm)	28	86	−9	97	0.07
LFTC (µm)	−8	76	−2	122	0.80
cMFTC (µm)	20	130	−8	150	0.37
cLFTC (µm)	27	113	25	180	0.95
PASE	−9.7	67	5.2	103	0.43
WOMAC Fct	−0.31	1.95	0.07	0.78	0.26
CST Pace (stands/s)	0.01	0.15	0.01	0.17	0.85
20m Pace (m/s)	0.02	0.12	−0.04	0.13	0.02

^aChange Score = location independent cartilage thickness change score; Thinning Score = location independent cartilage thinning score; Thickening Score = location independent cartilage thickening score. Other abbreviations: See Table 1 .