Table 2.

Treatment Regimens of Randomized Controlled Trials Included in the Meta-Analysis.

Study	Blinding			HA Characteristics						Follow-up (Days)
	Subjects	Injectors	Outcome Assessors	Trade Name	US Approved	Cross-Linked	Avian Origin	MW (kDa)	No. Injections
Altman, 1998 34	Yes	No	No	HYALGAN	Yes	No	Yes	730	5	182
Altman, 2004 35	Yes	No	Yes	DUROLANE	Yes	Yes	No	9000	1	182
Altman, 2009 36	Yes	No	Yes	EUFLEXXA	Yes	No	No	3600	3	182
Arden, 2014 37	Yes	No	Yes	DUROLANE	Yes	Yes	No	9000	1	42
Baltzer, 2009 38	Yes	No	Yes	HYA-JECT	No	No	No	1400	3	203
Brandt, 2001 26	Yes	No	Yes	ORTHOVISC	Yes	No	No	2900	3	189
Chevalier, 2010 39	Yes	No	Yes	SYNVISC	Yes	Yes	Yes	6000	1	182
Day, 2004 40	Yes	No	Yes	ARTZAL	Yes	No	Yes	1170	5	126
Dickson, 2001 41	Yes	No	Yes	SYNVISC	Yes	Yes	Yes	6000	3	84
Dixon, 1988 25	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	11	336
Dougados, 1993 42	No	No	No	HYALGAN	Yes	No	Yes	730	4	364
Hangody, 2017 43	Yes	Yes	Yes	MONOVISC	Yes	Yes	No	2900	1	182
Henderson, 1994 44	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	5	35
Henrotin, 2017 45	Yes	Yes	Yes	KARTILAGE CROSS	No	No	No	a	1	180
Huang, 2011 46	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	5	175
Huskisson, 1999 47	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	5	182
Jorgensen, 2010 48	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	5	91
Karlsson, 2002a 49	Yes	No	Yes	ARTZAL	Yes	No	Yes	1170	3	182
Karlsson, 2002b 49	Yes	No	Yes	SYNVISC	Yes	Yes	Yes	6000	3	182
Kosuwon, 2012 50	Yes	No	Yes	GO-ON	No	No	No	1500	5	182
Lohmander, 1996 27	Yes	No	Yes	ARTZAL	Yes	No	Yes	1170	5	185
Lundsgaard, 2008 51	Yes	No	Yes	HYALGAN	Yes	No	Yes	730	4	182
Neustadt, 2005 52	Yes	No	Yes	ORTHOVISC	Yes	No	No	2900	4	196
Petrella, 2002 53	Yes	Yes	Yes	SUPLASYN	No	Yes	No	1000	3	84
Petrella, 2006 54	Yes	No	Yes	SUPLASYN	No	Yes	No	1000	3	84
Petrella, 2008a 55	Yes	No	No	HYALGAN	Yes	No	Yes	730	3	728
Petrella, 2008b 55	Yes	No	No	SYNVISC	Yes	Yes	Yes	6000	3	728
Petterson, 2018 56	Yes	Yes	Yes	MONOVISC	Yes	Yes	No	2900	1	182
Pham, 2004 57	Yes	No	Yes	NRD101	No	a	No	1900	3	365
Puhl, 1993 58	Yes	No	Yes	ARTZAL	Yes	No	Yes	1170	5	98
Rolf, 2005a 59	Yes	No	Yes	SYNVISC	Yes	Yes	Yes	6000	3	364
Rolf, 2005b 59	Yes	No	Yes	ARTZAL	Yes	No	Yes	1170	3	364
Saravanan, 2002 60	No	No	No	SYNVISC	Yes	Yes	Yes	6000	3	42
Seikagaku, 2001 61	Yes	No	No	ARTZAL	Yes	No	Yes	1170	3	126
Shichikawa, 1983 62	Yes	No	No	NOT REPORTED	No	a	a	a	5	35
Strand, 2012 63	Yes	No	Yes	GEL-ONE	Yes	Yes	Yes	a	1	91
Wobig, 1998 64	Yes	Yes	Yes	SYNVISC	Yes	Yes	Yes	6000	3	182
Wu, 1997 65	Yes	No	No	ARTZAL	Yes	No	Yes	1170	5	182

HA = hyaluronic acid; MW = molecular weight; US = United States.

^aValues not reported.