Table 5.
Median Values (Quantitative Variables) or Number of Subjects (Qualitative Variable) for Baseline Biomarkers sColl2-1, Coll2-1NO2, Demographics, Pain and Function, and Structural Knee Features According to Knee OA Progression at 1 Year Assessed with WORMS (Total, Cartilage, and BML), Pain (VAS) and Function (KOOS) a .
| Progression Criteria | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WORMS Total |
WORMS Cartilage |
WORMS BML |
VAS Pain |
KOOS | ||||||
| Baseline Data | Prog. | No Prog. | Prog. | No Prog. | Prog. | No Prog. | Prog. | No Prog. | Prog. | No Prog. |
| Biomarkers | ||||||||||
| Coll2-1 (nM) | 494 | 477 | 544 | 478 | 498 | 458 | 495 | 467 | 450 | 495 |
| Coll2-1NO2 (pg/mL) | 312 | 331 | 374 | 312 | 327 | 330 | 428 | 306* | 350 | 310 |
| Demographics | ||||||||||
| Age (years) | 64 | 62.5 | 69 | 62* | 62 | 63 | 63 | 63 | 64 | 63 |
| BMI (kg/m2) | 28.9 | 29.4 | 33.9 | 28.9* | 28.9 | 29.8 | 28.0 | 30.0 | 29.1 | 29.9 |
| Gender (male/female) | 8/21 | 34/36 | 7/9 | 35/48 | 13/25 | 29/32 | 14/18 | 27/35 | 8/26 | 36/38* |
| PolyOA (yes/no) | 27/2 | 47/23* | 11/5 | 63/20 | 32/6 | 42/19 | 27/5 | 43/19 | 25/9 | 57/17 |
| Pain | ||||||||||
| Pain Intensity Scale (mm) | 44 | 24* | 45 | 32 | 37 | 28 | 13 | 43* | 20 | 36 |
| Pain Impact Scale (mm) | 48 | 29* | 41 | 30 | 31 | 37 | 13 | 44* | 22 | 41 |
| Structure—X-rays | ||||||||||
| KL grade (grade II/grade III) | 8/16 | 35/27 | 4/11 | 39/32 | 14/20 | 29/23 | 11/17 | 33/20 | 19/9 | 30/35 |
| Function | ||||||||||
| KOOS Pain | 53 | 66* | 53 | 61 | 57 | 64 | 67 | 61 | 67 | 58* |
| KOOS Symptoms | 54 | 71* | 59 | 64 | 57 | 71* | 70 | 61 | 70 | 59 |
| KOOS Function in daily living | 57 | 71* | 66 | 66 | 59 | 69 | 69 | 66 | 70 | 63 |
| KOOS Function in sport and recreation | 25 | 40 | 25 | 40 | 25 | 40 | 40 | 38 | 38 | 30 |
| KOOS Knee-related quality of life | 38 | 44 | 44 | 44 | 44 | 44 | 50 | 40 | 60 | 38* |
| Structure—WORMS MRI | ||||||||||
| Total | 81 | 74 | 107 | 75* | 81 | 74 | 73 | 76 | 71 | 81 |
| Articular cartilage integrity | 32 | 32 | 39 | 32 | 32 | 32 | 32 | 32 | 27 | 35 |
| Subarticular bone marrow abnormality (BML) | 5 | 3 | 5 | 3* | 3 | 4 | 3 | 3 | 4 | 3 |
| Total lateral meniscal integrity | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
| Total medial meniscal integrity | 4 | 4 | 5 | 4 | 4 | 3 | 4 | 4 | 3 | 4* |
| Subarticular cysts | 4 | 2* | 4 | 3* | 3 | 3 | 3 | 2 | 3 | 3 |
| Ligaments integrity | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Osteophytes | 27 | 29 | 44 | 28 | 34 | 27 | 28 | 28 | 28 | 29 |
| Periarticular cysts/bursitis | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
| Synovitis/effusion | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1* |
| Intraarticular Loose bodies | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Subarticular bone attrition | 1 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 1 |
WORMS = Whole-Organ Magnetic Resonance Imaging Score; BML = bone marrow lesion; VAS = Visual Analogue Scale; BMI = body mass index; KL = Kellgren and Lawrence; KOOS = Knee Injury and Osteoarthritis Outcome Score; MRI = magnetic resonance imaging.
a
Asterisk represents P < 0.05 with Mann-Whitney test or bilateral Fisher exact test.
Bold indicate values which are different between progressors and non- progressors