Table 1.
Patients Characteristics of the Included Studies.
| Study | Type of Control | Patients (Knees)
Included |
Patients (Knees)
Follow-up |
Sex |
Age |
BMI |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PRP | Control | PRP | Control | PRP | Control | PRP | Control | PRP | Control | ||
| Ahmad, 2018 59 | HA | 45 (45) | 45 (45) | 45 (45) | 44 (44) | M14, F31 | M15, F30 | 56.2 ± 6.8 | 56.8 ± 7.4 | 26.7 ± 3.6 | 26.5 ± 3.5 |
| Buendía-López, 2019 60 | HA | 35 (35) | 36 (36) | 33 (33) | 32 (32) | M16, F17 | M15, F17 | 56.2 ± 3 | 56.6 ± 2.9 | 24.9 ± 0.3 | 24.9 ± 0.4 |
| Cerza, 2012 61 | HA | 60 (60) | 60 (60) | 60 (60) | 60 (60) | M25, F35 | M28, F32 | 66.5 ± 11.3 | 66.2 ± 10.6 | NR | NR |
| Cole, 2016 53 | HA | 52 (52) | 59 (59) | 49 (49) | 50 (50) | M28, F21 | M20, F30 | 55.9 ± 10.4 | 56.8 ± 10.5 | 27.4 ± 3.9 | 29 ± 6.4 |
| Di Martino, 2019 13 | HA | 96 (96) | 93 (93) | 85 (85) | 82 (82) | M53, F32 | M47, F35 | 52.7 ± 13.2 | 57.5 ± 11.7 | 27.2 ± 7.6 | 26.8 ± 4.3 |
| Duymus, 2017 22 | HA or ozone | 41 (41) | HA 40 (40) Ozone 39 (39) |
33 (33) | HA 34 (34) Ozone 35 (35) |
M1, F32 | HA M1, F33 Ozone M4, F31 |
60.4 ± 5.1 | HA 60.3 ± 9.1 Ozone 59.4 ± 5.7 |
27.6 ± 4.6 | HA 28.4 ± 3.6 Ozone 27.6 ± 4.4 |
| Elik, 2019 62 | Saline | 30 (30) | 30 (30) | 30 (30) | 27 (27) | M1, F29 | M3, F24 | 61.3 ± 7.91 | 60.19 ± 6.8 | 30.37 ± 4.5 | 30.7 ± 4.0 |
| Filardo, 2015 23 | HA | 96 (96) | 96 (96) | 94 (94) | 89 (89) | M60, F34 | M52, F37 | 53.32 ± 13.2 | 57.55 ± 11.8 | 26.6 ± 4 | 26.9 ± 4.4 |
| Forogh, 2016 63 | CS | 24 (24) | 24 (24) | 23 (23) | 16 (16) | M7, F17 | M9, F15 | 59.13 ± 7.03 | 61.13 ± 6.7 | 28.9 ± 2.9 | 29.2 ± 3.4 |
| de Menezes Freire, 2018 64 | CS | 25 (25) | 25 (25) | 25 (25) | 25 (25) | NR | NR | 64.15 ± 8.02 | 60.2 ± 5.9 | 76% overweight | 88% overweight |
| Gaballa, 2019 28 | Ozone | 20 (20) | 20 (20) | 20 (20) | 20 (20) | M5, F15 | M4, F16 | 53.6 ± 4.6 | 56.3 ± 4.4 | NR | NR |
| Ghai, 2019 65 | Saline | 20 (20) | 20 (20) | 20 (20) | 20 (20) | M5, F15 | M5, F15 | 49.8 ± 9.4 | 49.8 ± 9.4 | NR | NR |
| Görmeli, 2017 66 | HA or saline | 46 (46) | Saline 45 (45) 3× HA 46 (46) |
39 (39) | Saline 40 (40) 3× HA 39 (39) |
M16, F23 | S M20, F20 HA M17, F22 |
53.7 ± 13.1 | S 52.8 ± 12.8 HA 53.5 ± 14 |
28.7 ± 4.8 | S 29.5 ± 3.2 HA 29.7 ± 3.7 |
| Montañez-Heredia, 2016 67 | HA | 28 (28) | 27 (27) | 27 (27) | 26 (26) | M12, F15 | M9, F17 | 66.3 ± 8.3 | 61.5 ± 8.6 | 29 ± 5.5 | 30.4 ± 4.9 |
| Huang, 2019 26 | HA or CS | 40 (40) | HA 40 (40) CS 40 (40) |
40 (40) | HA 40 (40) CS 40 (40) |
M25, F15 | HA M19, F21 CS M21, F19 |
54.5 ± 1.2 | HA 54.8 ± 1.1 CS 54.3 ± 1.4 |
25.2 ± 4.2 | HA 25.4 ± 3.1 CS 24.6 ± 3.6 |
| Joshi Jubert, 2017 68 | CS + anesthetic | 35 (35) | 30 (30) | 34 (34) | 30 (30) | M12, F23 | M6, F24 | 65.56 ± 8.6 | 68 ± 7.2 | 31.2 ± 4.4 | 31.0 ± 4.2 |
| Kon, 2017 33 | Saline | 31 (31) | 15 (15) | 29 (29) | 14 (14) | M18, F13 | M9, F6 | 57 (41-68) | 54 (44-67) | NR | NR |
| Lana, 2016 69 | HA | 36 (36) | 36 (36) | 36 (36) | 36 (36) | M7, F29 | M3, F33 | 60.9 ± 7 | 60 ± 6.6 | 27.4 ± 6.9 | 28.2 ± 8.8 |
| Lin, 2019 24 | HA or saline | 31 (31) | HA 29 (29) Saline 27 (27) |
30 (30) | HA 27 (27) Saline 26 (26) |
M9, F22 | HA M10, F19 S M10, F17 |
61.2 ± 13.1 | HA 62.5 ± 3.0 S 62.2 ± 3.1 |
24.0 ± 2.6 | HA 26.3 ± 3.0 S 25.0 ± 3.1 |
| Lisi, 2018 70 | HA | 31 (31) | 31 (31) | 31 (31) | 31 (31) | M20, F10 | M16, F12 | 53.5 ± 15.1 | 57.1 ± 10.0 | NR | NR |
| Louis, 2017 52 | HA | 28 (NR) | 28 (NR) | 17 (NR) | 17 (NR) | M14, F10 | M11, F13 | 53.2 ± 11.7 | 48.5 ± 11.5 | 25.6 ± 2.9 | 27.0 ± 2.9 |
| Nabi, 2018 71 | CS | 36 (36) | 36 (36) | 33 (33) | 34 (34) | M5, F28 | M7, F27 | 50.09 ± 7.79 | 58.6 ± 8.8 | 28.4 ± 2.8 | 27.8 ± 3.3 |
| Papalia, 2016 72 | HA | 24 (NR) | 24 (NR) | 23 (NR) | 24 (NR) | NR | NR | NR | NR | NR | NR |
| Patel, 2013 73 | Saline | 27 (54) | 26 (52) | 26 (52) | 23 (46) | M11, F16 | M6, F17 | 53.1 ± 11.6 | 53.7 ± 8.2 | 26.3 ± 3.2 | 26.2 ± 2.9 |
| Paterson, 2016 74 | HA | 12 (12) | 11 (11) | 10 (10) | 9 (9) | M8, F3 | M7, F3 | 49.9 ± 13.7 | 52.7 ± 10.3 | 27.9 ± 11.9 | 30.9 ± 5.6 |
| Raeissadat, 2015 25 | HA | 87 (87) | 73 (73) | 77 (77) | 62 (62) | M8, F69 | M15, F47 | 56.9 ± 9.1 | 61.1 ± 7.5 | 28.2 ± 4.6 | 27.0 ± 4.2 |
| Raeissadat, 2017 75 | HA | 41 (41) | 36 (36) | 36 (36) | 33 (33) | M7, F29 | M6, F27 | 57.0 ± 7.2 | 59.5 ± 7.5 | 28.6 ± 2.8 | 27.5 ± 2.9 |
| Rahimzadeh, 2018 29 | Dextrose | 21 (21) | 21 (21) | 21 (21) | 21 (21) | M10, F11 | M11, F10 | 65.5 ± 6.6 | 64.3 ± 5.3 | 28.6 ± 1.8 | 28.3 ± 1.9 |
| Sánchez, 2012 76 | HA | 89 (89) | 87 (87) | 79 (79) | 74 (74) | M43, F46 | M29, F45 | 60.5 ± 7.9 | 58.9 ± 8.2 | 27.9 ± 2.9 | 28.2 ± 2.7 |
| Smith, 2016 77 | Saline | 15 (15) | 15 (15) | 15 (15) | 15 (15) | M5, F10 | M6, F9 | 53.5 ± 8.2 | 46.6 ± 9.4 | 29.5 ± 6.9 | 27.5 ± 4.8 |
| Su, 2018 78 | HA | 26 (26) | 32 (32) | 25 (25) | 30 (30) | M11, F14 | M12, F18 | 54.2 ± 6.6 | 53.13 ± 6.4 | 28.17 ± 1.4 | 28.7 ± 1.1 |
| Güvendi, 2018 27 | CS | 19 (19) | 19 (19) | 19 (19) | 17 (17) | M1, F18 | M2, F15 | 62.3 ± 1.6 | 62.8 ± 1.7 | 31.4 ± 0.7 | 31.1 ± 1.0 |
| Vaquerizo, 2013 79 | HA | 48 (48) | 48 (48) | 48 (48) | 42 (42) | M16, F32 | M22, F26 | 62.4 ± 6.6 | 64.8 ± 7.7 | 30.7 ± 3.6 | 31.0 ± 4.6 |
| Wu, 2018 80 | Saline | 20 (20) | 20 (20) | 20 (20) | 20 (20) | M5, F15 | M1, F15 | 63.3 ± 6.8 | 63.3 ± 6.8 | 24.1 ± 2.9 | 24.1 ± 2.9 |
BMI = body mass index; PRP = platelet-rich plasma; HA = hyaluronic acid; M = males; F = females; NR = non-reported; CS = corticosteroid.