Table 1.
Basal Characteristics, Radiographic Status, Clinical Severity Indexes, and Adipokines and Inflammatory Markers Levels in Synovial Fluid and Serum Stratified by Obesity Status. a
| Nonobese, n = 50 (43.5%) | Obese, n = 65 (56.5%) | All, n = 115 (100%) | |
|---|---|---|---|
| Age, years | 68.6 (11.6) | 68.8 (11.1) | 68.8 (11.0) |
| Evolution time, months | 55.0 (66.8) | 46.0 (75.0) | 50.0 (73.0) |
| BMI, kg/m2 | 27.1 (3.2) | 34.0 (4.5) | 30.5 (6.4) |
| Physical exercise | |||
| None | 16 (32.0%) | 37 (56.9%) | 53 (46.1%) |
| Occasional | 13 (26.0%) | 15 (23.1%) | 28 (24.3%) |
| Regular | 21 (42.0%) | 13 (20.0%) | 34 (29.6%) |
| Kellgren-Lawrence grade | |||
| 1 | 4 (8.0%) | 11 (16.9%) | 15 (13.0%) |
| 2 | 23 (46.0%) | 25 (38.5%) | 48 (41.7%) |
| 3 | 23 (46.0%) | 25 (38.5%) | 48 (41.7%) |
| 4 | 0 (0.0%) | 4 (6.2%) | 4 (3.5%) |
| WOMAC score | |||
| Pain | 10.0 (3.8) | 11.0 (3.0) | 11.0 (3.5) |
| Function | 36.0 (14.8) | 38.0 (14.0) | 37.0 (13.5) |
| Total | 48.0 (19.5) | 52.00 (21.0) | 52.0 (20.0) |
| Leptin SF, pg/mL | 33210.7 (18304.4) | 53232.3 (32845.8) | 42079.4 (29566.0) |
| Adiponectin SF, ng/mL | 2118.6 (1910.0) | 1590.1 (1003.7) | 1734.8 (1352.5) |
| TNF-α SF, pg/mL | 10.04 (8.11) | 10.16 (7.17) | 10.19 (7.97) |
| hsCRP SF, mg/mL | 0.75 (0.80) | 1.06 (0.83) | 0.91 (0.76) |
| IL-6 SF, pg/mL | 94.9 (274.1) | 122.2 (334.0) | 106.0(302.6) |
| Leptin serum, pg/mL | 28752.9 (21950.2) | 44409.2 (32622.9) | 37948.0 (28243.8) |
| Adiponectin serum, ng/mL | 18333.2 (11489.5) | 12471.6 (8681.5) | 14294.1 (9990.2) |
| TNF-α serum, pg/mL | 5.50 (1.83) | 6.00 (2.06) | 5.64 (1.95) |
| hsCRP serum, mg/mL | 4.01 (6.49) | 5.12 (5.16) | 4.92 (6.11) |
| IL-6 serum, pg/mL | 2.41 (3.29) | 2.91 (3.02) | 2.72 (3.31) |
BMI = body mass index; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; SF = synovial fluid; TNF-α = tumor necrosis factor–alpha; hsCRP = high-sensitivity C-reactive protein; IL6 = interleukin-6.
a
Variables are described by total frequency and percentages (categorical) or median and interquartile range (numerical). Adipokines and inflammatory factors were a priori corrected by round of measurement before summarization.