Table 2.

Associations between Synovial Fluid Leptin and Adiponectin with Clinical Severity Indexes and Synovial Fluid Inflammatory Markers.

	SF Leptin				SF Adiponectin
	Univariate		Adjusted a		Univariate		Adjusted a
	Nonobese PCC [95% CI]	Obese PCC [95% CI]	Nonobese PCC [95% CI]	Obese PCC [95% CI]	Nonobese PCC [95% CI]	Obese PCC [95% CI]	Nonobese PCC [95% CI]	Obese PCC [95% CI]
WOMAC pain	0.375 [0.088, 0.605]**	0.112 [−0.146, 0.356]	0.258 [−0.068, 0.533]	−0.037 [−0.302, 0.233]	0.346 [0.065, 0.576]**	−0.087 [−0.330, 0.166]	0.395 [0.100, 0.627]**	0.013 [−0.251, 0.275]
WOMAC function	0.276 [−0.023, 0.529]*	0.257 [0.003, 0.480]**	0.170 [−0.158, 0.465]	0.059 [−0.212, 0.322]	0.350 [0.069, 0.579]**	−0.236 [−0.459, 0.015]*	0.387 [0.090, 0.621]**	−0.114 [−0.366, 0.154]
WOMAC total	0.339 [0.047, 0.578]**	0.211 [−0.045, 0.442]	0.244 [−0.082, 0.523]	0.011 [−0.257, 0.278]	0.384 [0.108, 0.604]***	−0.210 [−0.437, 0.042]	0.427 [0.138, 0.650]***	−0.096 [−0.350, 0.171]
TNF-α SF	0.040 [−0.288, 0.359]	0.045 [−0.219, 0.302]	−0.044 [−0.392, 0.316]	0.078 [−0.202, 0.346]	0.018 [−0.299, 0.332]	0.249 [−0.008, 0.474]*	0.175 [−0.179, 0.489]	0.308 [0.041, 0.533]**
hsCRP SF	0.349 [0.058, 0.585]**	−0.007 [−0.261, 0.247]	0.252 [−0.074, 0.529]	−0.058 [−0.321, 0.213]	0.021 [−0.268, 0.306]	−0.029 [−0.276, 0.223]	0.137 [−0.178, 0.426]	0.020 [−0.244, 0.282]
IL 6 SF	0.305 [0.005, 0.555]**	0.002 [−0.252, 0.256]	0.358 [0.038, 0.611]**	0.032 [−0.238, 0.297]	0.577 [0.344, 0.743]****	0.238 [−0.013, 0.460]*	0.649 [0.423, 0.799]****	0.249 [−0.015, 0.481]*

PCC = partial correlation coefficient; CI = confidence interval; SF = synovial fluid; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; TNF-α = tumor necrosis factor–alpha; hsCRP = high-sensitivity C-reactive protein; IL-6 = interleukin-6.

The boldfaced entries are for statistically significant values.

^aControlled for age, evolution time, body mass index, physical exercise, and Kellgren-Lawrence grade.

^*0.1 < P < 0.05, **P < 0.05, ***P < 0.01, ****P < 0.001.