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. 2020 Feb 20;13(1 Suppl):1675S–1683S. doi: 10.1177/1947603520904776

Table 5.

Associations between Leptin and Adiponectin Ratio in Synovial Fluid and Serum with Clinical Severity Indexes and Synovial Fluid and Serum Inflammatory Markers.

Leptin/Adiponectin SF Leptin/Adiponectin Serum
Univariate Adjusted a Univariate Adjusted a
Nonobese PCC [95% CI] Obese PCC [95% CI] Nonobese PCC [95% CI] Obese PCC [95% CI] Nonobese PCC [95% CI] Obese PCC [95% CI] Nonobese PCC [95% CI] Obese PCC [95% CI]
WOMAC pain −0.125 [−0.398, 0.168] 0.138 [−0.113, 0.373] −0.284 [−0.553, 0.039]* −0.043 [−0.307, 0.227] 0.046 [−0.235, 0.321] 0.198 [−0.050, 0.423] −0.170 [−0.454, 0.145] 0.113 [−0.157, 0.367]
WOMAC function −0.167 [−0.434, 0.126] 0.331 [0.090, 0.535]*** −0.292 [−0.559, 0.031]* 0.120 [−0.153, 0.376] 0.107 [−0.177, 0.374] 0.223 [−0.024, 0.444]* −0.061 [−0.362, 0.251] 0.095 [−0.175, 0.351]
WOMAC total −0.173 [−0.438, 0.121] 0.282 [0.037, 0.495]** −0.300 [−0.566, 0.021]* 0.071 [−0.201, 0.332] 0.118 [−0.166, 0.384] 0.210 [−0.038, 0.433]* −0.056 [−0.357, 0.256] 0.098 [−0.172, 0.354]
TNF-α SF 0.047 [−0.281, 0.366] −0.114 [−0.364, 0.151] −0.162 [−0.489, 0.204] −0.147 [−0.406, 0.134] 0.117 [−0.206, 0.417] 0.174 [−0.088, 0.414] 0.029 [−0.318, 0.368] 0.210 [−0.066, 0.457]
hsCRP SF 0.191 [−0.113, 0.461] 0.025 [−0.231, 0.277] −0.006 [−0.325, 0.315] −0.039 [−0.304, 0.231] 0.144 [−0.149, 0.414] 0.058 [−0.196, 0.306] −0.011 [−0.317, 0.298] 0.076 [−0.193, 0.335]
IL-6 SF −0.373 [−0.606, −0.082]** −0.166 [−0.403, 0.092] −0.475 [−0.692, −0.178]*** −0.186 [−0.432, 0.086] −0.030 [−0.318, 0.262] 0.266 [0.015, 0.485]** −0.057 [−0.362, 0.259] 0.362 [0.106, 0.572]***
TNF-α serum −0.092 [−0.379, 0.210] −0.179 [−0.416, 0.081] −0.030 [−0.346, 0.293] −0.174 [−0.424, 0.102] 0.009 [−0.279, 0.295] 0.036 [−0.218, 0.285] 0.125 [−0.189, 0.417] 0.099 [−0.171, 0.355]
hsCRP serum 0.054 [−0.247, 0.345] 0.215 [−0.044, 0.446] −0.194 [−0.484, 0.134] 0.125 [−0.150, 0.382] −0.002 [−0.289, 0.285] 0.171 [−0.084, 0.406] −0.190 [−0.470, 0.125] 0.128 [−0.142, 0.380]
IL-6 serum 0.225 [−0.077, 0.489] 0.114 [−0.146, 0.360] 0.091 [−0.235, 0.399] 0.117 [−0.159, 0.375] 0.199 [−0.094, 0.459] 0.386 [0.149, 0.581]*** 0.159 [−0.156, 0.445] 0.450 [0.210, 0.639]****

SF = synovial fluid; WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; TNF-α = tumor necrosis factor–alpha; hsCRP = high-sensitivity C-reactive protein; IL-6 = interleukin-6.

The boldfaced entries are for statistically significant values.

a

Controlled for age, evolution time, body mass index, physical exercise, and Kellgren-Lawrence scale.

*

0.1 < P < 0.05, **P < 0.05, ***P < 0.01, ****P < 0.001.