Table 1.
Demographic Data of Each Group.
| Normal (n = 663) | Medial (n = 363) | Lateral (n = 268) | Medial & Lateral (n = 959) | Analysis Population (n = 2,253) | |
|---|---|---|---|---|---|
| Age, years, mean (SD) | 67.7 (5.0) | 67.4 (4.9) | 69.1 (5.0) | 69.7 (5.2) | 68.7 (5.2) |
| Female | 349, 52.6 | 280, 77.1 | 102, 38.1 | 712, 74.2 | 1,443, 64.1 |
| BMI, kg/m2, mean (SD) | 21.5 (2.8) | 22.0 (3.1) | 22.5 (3.0) | 23.1 (3.2) | 22.4 (3.1) |
| Radiographic severity | |||||
| K/L grade 0 | 93, 14.0 | 1, 0.3 | 3, 1.1 | 0, 0 | 97, 4.3 |
| K/L grade 1 | 557, 84.0 | 259, 71.4 | 255, 95.2 | 191, 19.9 | 1262, 56.0 |
| K/L grade 2 | 13, 2.0 | 91, 25.1 | 9, 3.4 | 568, 59.2 | 681, 30.2 |
| K/L grade 3 | 0, 0 | 12, 3.3 | 1, 0.4 | 183, 18.9 | 194, 8.6 |
| K/L grade 4 | 0, 0 | 0, 0 | 0, 0 | 19, 2.0 | 19, 0.8 |
| OARSI atlas | |||||
| Medial femoral osteophyte | |||||
| Grade 0 (normal) | 344, 51.9 | 1, 0.3 | 147, 54.9 | 1, 0.1 | 493, 21.9 |
| Grade 1 (mild) | 319, 48.1 | 343, 94.5 | 121, 45.2 | 658, 68.6 | 1441, 64.0 |
| Grade 2 (moderate) | 0, 0 | 18, 5.0 | 0, 0 | 217, 22.6 | 235, 10.4 |
| Grade 3 (severe) | 0, 0 | 1, 0.3 | 0, 0 | 83, 8.7 | 84, 3.7 |
| Medial tibial osteophyte | |||||
| Grade 0 (normal) | 540, 81.5 | 2, 0.6 | 200, 74.6 | 4, 0.4 | 746, 33.1 |
| Grade 1 (mild) | 123, 18.6 | 349, 96.1 | 68, 25.4 | 711, 74.1 | 1251, 55.5 |
| Grade 2 (moderate) | 0, 0 | 11, 3.0 | 0, 0 | 198, 20.7 | 209, 9.3 |
| Grade 3 (severe) | 0, 0 | 1, 0.3 | 0, 0 | 46, 4.8 | 47, 2.1 |
| Medial joint space narrowing | |||||
| Grade 0 (normal) | 661, 99.7 | 336, 92.6 | 267, 99.6 | 679, 70.8 | 1943, 86.2 |
| Grade 1 (mild) | 2, 0.3 | 23, 6.3 | 1, 0.4 | 183, 19.1 | 209, 9.3 |
| Grade 2 (moderate) | 0, 0 | 3, 0.8 | 0, 0 | 60, 6.3 | 63, 2.8 |
| Grade 3 (severe) | 0, 0 | 1, 0.3 | 0, 0 | 37, 3.9 | 38, 1.7 |
| Lateral femoral osteophyte | |||||
| Grade 0 (normal) | 441, 66.5 | 282, 77.7 | 3, 1.1 | 5, 0.5 | 731, 32.5 |
| Grade 1 (mild) | 222, 33.5 | 81, 22.3 | 258, 96.3 | 769, 80.2 | 1330, 59.0 |
| Grade 2 (moderate) | 0, 0 | 0, 0 | 6, 2.2 | 156, 16.3 | 162, 7.2 |
| Grade 3 (severe) | 0, 0 | 0, 0 | 1, 0.4 | 29, 3.0 | 30, 1.3 |
| Lateral tibial osteophyte | |||||
| Grade 0 (normal) | 473, 71.3 | 173, 47.7 | 1, 0.4 | 1, 0.1 | 648, 28.8 |
| Grade 1 (mild) | 190, 28.7 | 190, 52.3 | 256, 95.5 | 744, 77.6 | 1380, 61.3 |
| Grade 2 (moderate) | 0, 0 | 0, 0 | 11, 4.1 | 173, 18.0 | 184, 8.2 |
| Grade 3 (severe) | 0, 0 | 0, 0 | 0, 0 | 41, 4.3 | 41, 1.8 |
| Lateral joint space narrowing | |||||
| Grade 0 (normal) | 662, 99.9 | 363, 100 | 268, 100 | 901, 94.0 | 2194, 97.4 |
| Grade 1 (mild) | 1, 0.2 | 0, 0 | 0, 0 | 46, 4.8 | 47, 2.1 |
| Grade 2 (moderate) | 0, 0 | 0, 0 | 0, 0 | 6, 0.6 | 6, 0.3 |
| Grade 3 (severe) | 0, 0 | 0, 0 | 0, 0 | 6, 0.6 | 6, 0.3 |
BMI = body mass index; K/L = Kellgren/Lawrence; OARSI = Osteoarthritis Research Society International.
a
Values are n, %, except where otherwise indicated.