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. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: ACS Chem Biol. 2020 Dec 4;15(12):3124–3132. doi: 10.1021/acschembio.0c00277

Figure 8.

Figure 8.

Helix curvature along the dimer hinge. (a-b) Hinges were abstracted using Bendix [44], fitting Bendices through residues 88–98. (c) The angle of helix curvature captures the deviation from linearity. The hinge vertex is at Val93. (d) The distribution of hinge angles is larger by 3° for half-dimers with helical (blue) versus partial helical (red) secondary structure in helix 4a. A shift of 3° per half-dimer corresponds to widening the spike tip opening by 2 Å. Curvature angles measured for dimers in crystal structures (PDB: 1QGT, 2G33, and 3KXS) are indicated (black).