Table 6.

Comparison of lung function indices and six minute walking distance in coronavirus disease 2019 survivors who had required intensive care unit care (n=25) versus those treated on the wards (n=60)

	ICU/no ICU		P
	3 months	6 months
FVC (% predicted)
Mean±SD	93.5±14.0 versus 107.5±12.1	97.6±15.8 versus 106.8±13.5	4.1±1.7 versus−0.7±1.0
95% CI	7.9-19.2	1.5-15.2	−9.6-−2.1
P	−0.01*	−0.02*	−0.01*
FEV1 (% predicted)
Mean±SD	102.0±13.1 versus 111.1±14.7	103.8±12.7 versus 108.2±15.4	1.8±1.2 versus−2.9±1.3
95% CI	3.0-15.1	−1.8-10.6	−9.0-−0.4
P	−0.01*	−0.17	−0.03*
TLC (% predicted)
Mean±SD	94.6±16.1 versus 110.3±16.4	98.2±19.3 versus 110.1±14.1	3.6±3.9 versus−0.2±1.9
95% CI	8.7-20.5	5.0-18.7	−11.6-4.0
P	−0.01*	−0.01*	−0.03*
VC (% predicted)
Mean±SD	94.7±13.1 versus 107.9±12.5	98.4±16.4 versus 105.0±14.9	3.7±1.3 versus−2.8±1.5
95% CI	7.4-18.9	−0.9-14.1	−11.3-−1.9
P	−0.01*	−0.08	−0.01*
RV (% predicted)
Mean±SD	96.7±39.4 versus 115.7±45.2	99.9±52.6 versus 118.6±32.2	3.2±12.3 versus 2.9±7.2
95% CI	−1.3-38.2	−2.4-36.7	−25.0-24.3
P	−0.06	−0.08	−0.78
DLCO (% predicted)
Mean±SD	84.3±18.4 versus 101.3±12.4	87.7±22.3 versus 98.3±16.6	3.4±2.2 versus−2.9±1.6
95% CI	11.2-24.4	3.0-16.2	−11.9-−0.6
P	−0.01*	−0.01*	−0.03*
KCO (% predicted)
Mean±SD	104.9±13.5 versus 107.4±13.7	109.4±15.3 versus 110.2±15.6	4.5±1.7 versus 2.6±1.6
95% CI	−3.4-8.2	−5.3-6.9	−6.5-2.7
P	−0.41	−0.83	−0.38
6MWD (m)
Mean±SD	458.2±86.8 versus 466.4±80.7	519.7±101.4 versus 491.5±92.9	64.5±14.5 versus 25.1±9.7
95% CI	−27.1-42.5	−11.3-12.4	−74.9-−4.0
P	−0.64	−0.97	−0.03*

*Statistically significant. Values are shown as mean±SD ICU versus non-ICU with 95% CI of difference and P values. FVC=Forced vital capacity, FEV₁=Forced expiratory volume in 1 s, TLC=Total lung capacity, VC=Vital capacity, RV=Residual volume, DLCO=Diffusing capacity for carbon monoxide, KCO=Transfer coefficient (transfer factor per alveolar volume), SD=Standard deviation, 6MWD=Six minute walking distance, CI=Confidence interval, ICU=Intensive care unit