Table 1.
Baseline characteristics of patients with SJS-TEN
| Baseline Characteristics | Number of patients n=62 (%) | |
|---|---|---|
| Gender | Males | 20 (32.3) |
| Females | 42 (67.7) | |
| Age | Male:Female | 1:2.1 |
| Range (Mean±SD) | <20 y | 12 (19.4) |
| 4-85 (41.2±19.4) y | 21-40 y | 22 (35.5) |
| 41-60 y | 18 (29.0) | |
| 61-80 y | 9 (14.5) | |
| >80 y | 1 (1.6) | |
| Disease profile | SJS | 26 (41.9) |
| TEN | 21 (33.9) | |
| Overlap | 15 (24.2) | |
| Cutaneous and Extra cutaneous complications | Prodrome/Constitutional symptoms* | 58 (93.5) |
| Lymphadenopathy | 9 (14.5) | |
| Eosinophilia (AEC >450 cells/cmm) | 7 (11.3) | |
| LFT derangement | 43 (69.4) | |
| Bacteremia | 7 (11.3) | |
| Wound infection | 3 (4.8) | |
| Oral candidiasis | 2 (3.3) | |
| Latent interval | <10d | 21 (33.9) |
| Range: 1-60 d | 10-20d | 18 (29.0) |
| Median±IQR: (15.0±16.0, lower quartile=7, upper quartile=23) d; | 21-30 d | 19 (30.6) |
| Mean±SD 16.6±12.6 d | >30 d | 4 (6.5) |
| Primary Comorbidities | Seizure disorder | 13 (21) |
| Hyperuricemia/Gout | 11 (17.7) | |
| HIV infection | 8 (12.9) | |
| PUO | 7 (11.3) | |
| Major psychiatric disorder | 6 (9.7) | |
| Trauma/Surgery | 5 (8.1) | |
| Seizure prophylaxis in head injury/subdural hemorrhage/meningioma | 3 (4.8) | |
| Others comorbidities** | 9 (14.5) | |
HIV, human immunodeficiency virus; LFT, liver function tests; PUO, pyrexia of unknown origin; SD, standard deviation; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis; d, day; y, year; *Prodrome/Constitutional symptoms: fever (n=44), malaise (n=19), myalgia (n=7), arthralgia (n=7), sore throat (n=7), headache (n=5), nausea (n=4), diarrhea (n=2). **Others comorbidities include: rheumatoid arthritis (n=3), chronic kidney disease (n=3), toothache (n=2), pulmonary tuberculosis (n=1)