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. 2022 Feb 2;43(9):2429–2438. doi: 10.1038/s41401-021-00855-6

Fig. 1. HT-15 is a potent GR modulator.

Fig. 1

a The relative GR competitive binding activity of the potent compounds (10 µM) was analyzed using the LanthaScreen TR-FRET GR competitive binding assay (n = 3). b The chemical structures of Dex, HT-15, HT-34, and HT-36. c, d The transrepression activity of the compounds on the NF-κB and AP-1 signaling pathway (n = 4). e The evaluation of the HT-15 transactivation activity in the MMTV-Luc reporter assay (n = 4). f The inhibition activities of mifepristone, Azd9567, and HT-15 against Dex in the TAantag MMTV-Luc reporter assay (n = 4). g, h The toxicity of HT-15 on 3T3 and HepG2 cell lines (n = 3).