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KPT-9274 decreased phosphorylation of β-catenin and total PAK4 expression. Protein was extracted from RENCA tumors in mice treated with PD1 antibody (anti-PD1), KPT-9274, or a combination of both and was immunoblotted for (A) PAK4, (B) phospho-β-catenin (P-βcatenin), and β-actin. ImageJ quantification of phospho-β-catenin and PAK4 expression, each corrected for β-actin, are underneath a representative immunoblot from one tumor per mouse. Data are means±SEM (n=6). a,bP<0.05.
