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. Author manuscript; available in PMC: 2022 Feb 2.
Published in final edited form as: Addict Biol. 2021 Aug 25;27(1):e13097. doi: 10.1111/adb.13097

Figure 5.

Figure 5.

Inhibition and activation of the infralimbic (IL)-nucleus accumbens (NA)shell circuit and methamphetamine seeking in response to drug cues. A. Experimental timeline for experiments 7 and 8. B. Active and inactive lever responding (left axis) and meth infusions (right axis) over 15 daily 2 hr sessions. Self-administration data is combined for experiments represented in D and E. The individual graphs per experiment are disaggregated by sex and depicted in Supplemental Figure 5. C. Active and inactive lever responding over 10 daily extinction (Ext) sessions. Extinction data is combined for all experiments represented in D and E. The individual graphs per experiment are disaggregated by sex and depicted in Supplemental Figure 5. D. All groups increased active lever presses relative to extinction in rats with DIO-hM4Di in the IL. However, lever responding following 10 mg/kg CNO was significantly decreased relative to vehicle and 3 CNO tests. D. Reinstatement levels were similar in rats with DIO-hM3Dq in the IL in response to VEHICLE or CNO.

*Significant difference from 10 mg/kg CNO.

#Significant difference from extinction.