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. 2022 Jan 19;12:817236. doi: 10.3389/fphar.2021.817236

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Copyright © 2022 Bloomingdale, Meregalli, Pollard, Canta, Chiorazzi, Fumagalli, Monza, Pozzi, Alberti, Ballarini, Oggioni, Carlson, Liu, Ghandili, Ignatowski, Lee, Moore, Cavaletti and Mager.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of in vitro cytotoxicity of bortezomib and dexanabinol. Cell viability was measured using WST-1. (A) Cytotoxicity of SH-SY5Y cells exposed to various concentrations of bortezomib in the absence (red) or presence of 1 μM (green) and 10 μM (blue) dexanabinol. (B) Cytotoxicity of U266 multiple myeloma cells exposed to a range of bortezomib and dexanabinol concentrations for (left) 24, (middle) 48, and (right) 72 h. Antagonistic, additive, and synergistic pharmacological relationships are colored in red, green, and blue. (C) Concentration-effect relationship of dexanabinol on LPS-induced TNFα production in primary rat macrophages.