FIGURE 5.

Efficacy of dexanabinol for preventing bortezomib-induced mechanical allodynia and thermal hyperalgesia in rats. Mechanical threshold (grams) was determined using dynamic test at baseline, 4 weeks of treatment, and 8 weeks of treatment (A). The withdrawal latency to an infrared heat stimulus (seconds) was determined using a dynamic plantar analgesiometer at baseline, 4 weeks of treatment, and 8 weeks of treatment (B). Bortezomib (Bort) was administered IV (0.2 mg/kg) three times a week, and dexanabinol (Dex) was administered IP (10 mg/kg) three times a week approximately 30 min prior to bortezomib. GraphPad prism v7.04 was used to perform a Kruskal-Wallis test with Dunn’s correction for multiple comparisons across all groups. p values are reported as: Bort vs vehicle (Vehicle), ** (<0.01), *** (<0.001) and Bort vs Dex + Bort, ○ (<0.05), ○ ○ (<0.01).