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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Exp Eye Res. 2021 Dec 8;214:108882. doi: 10.1016/j.exer.2021.108882

Fig. 9. Immunohistochemical localization of microglia and macrophages near melanotic cells.

Fig. 9.

Fuchsia arrowhead, cells containing large spherical melanosomes. Blue, red reaction product. Yellow arrowhead, Bruch’s membrane. A, B. Immunoreactivity for Iba1 (A) and TMEM119 (B) localizes to fibrotic tissue between melanotic cells in the eye shown in Fig. 8GHIJ, as well as choroidal macrophages. Signal for TMEM119 is stronger overall and additionally localizes to overlying retina, in which ONL and HFL is completely degenerated. C. Immunoreactivity for TMEM119 localizes in areas between giant cells containing spherical melanosomes. D, E. Sham controls lacking primary antibody for Iba1 (D), in eye in A, and TMEM119 (E) in eye in C. BrM, Bruch’s membrane; fs, fibrotic scar; HFL, Henle fiber layer; INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium.