Table 2.
Correlation Between SOCS2 Variants and T2DM Risk
| SNPs ID | Models | Genotype | Case | Control | Adjusted by Age and Gender | |
|---|---|---|---|---|---|---|
| OR (95% CI) | p | |||||
| rs3825199 | Allele | A | 646 | 676 | 1 | |
| G | 354 | 326 | 1.14 (0.94–1.37) | 0.176 | ||
| Genotype | AA | 200 | 237 | 1 | ||
| AG | 246 | 202 | 1.44 (1.11–1.88) | 0.007* | ||
| GG | 54 | 62 | 1.03 (0.68–1.56) | 0.881 | ||
| Dominant | AG-GG vs AA | 1.35 (1.05–1.73) | 0.020 | |||
| Recessive | GG vs AA-AG | 0.86 (0.58–1.26) | 0.437 | |||
| Log-additive | AA+AG+GG | 1.14 (0.94–1.37) | 0.177 | |||
| rs11107116 | Allele | G | 653 | 679 | 1 | |
| T | 347 | 323 | 1.12 (0.93–1.35) | 0.243 | ||
| Genotype | GG | 205 | 238 | 1 | ||
| GT | 243 | 203 | 1.39 (1.07–1.81) | 0.014 | ||
| TT | 52 | 60 | 1.01 (0.66–1.52) | 0.978 | ||
| Dominant | GT-TT vs GG | 1.30 (1.01–1.67) | 0.038 | |||
| Recessive | TT vs GG-GT | 0.85 (0.58–1.27) | 0.430 | |||
| Log-additive | GG+GT+TT | 1.12 (0.93–1.35) | 0.243 | |||
| rs10492321 | Allele | T | 617 | 656 | 1 | |
| A | 383 | 346 | 1.18 (0.98–1.41) | 0.080 | ||
| Genotype | TT | 183 | 224 | 1 | ||
| TA | 251 | 208 | 1.48 (1.13–1.93) | 0.004* | ||
| AA | 66 | 69 | 1.17 (0.79–1.73) | 0.428 | ||
| Dominant | TA-AA vs TT | 1.40 (1.09–1.81) | 0.009* | |||
| Recessive | AA vs TT-TA | 0.95 (0.66–1.37) | 0.791 | |||
| Log-additive | TT+TA+AA | 1.18 (0.98–1.41) | 0.081 | |||
Notes: p values were calculated by logistic regression analysis with adjustments for age and gender. Bold values indicate that p < 0.05 means the data are statistically significant.*p indicates that after Bonferroni correction (p < 0.05/5) means the data are statistically significant.
Abbreviations: SNP, single-nucleotide polymorphism; T2DM, type 2 diabetes mellitus; OR, odds ratio; 95% CI, 95% confidence interval.