Table 6.

False-Positive Report Probability Values for the Associations Between SOCS2 Polymorphisms and T2DM Susceptibility

Group/SNPs ID	Model	OR (95% CI)	p	Statistical Power	Prior Probability
					0.25	0.1	0.01	0.001	0.0001
Overall
rs3825199	AG vs AA	1.44 (1.11–1.88)	0.007	0.618	0.034	0.097	0.541	0.922	0.992
	AG-GG vs AA	1.35 (1.05–1.73)	0.020	0.797	0.062	0.167	0.687	0.957	0.996
rs11107116	GT vs GG	1.39 (1.07–1.81)	0.014	0.714	0.057	0.155	0.668	0.953	0.995
	GT-TT vs GG	1.30 (1.01–1.67)	0.038	0.869	0.122	0.293	0.820	0.979	0.998
rs10492321	TA vs TT	1.48 (1.13–1.93)	0.004	0.539	0.021	0.060	0.411	0.876	0.986
	TA-AA vs TT	1.40 (1.09–1.81)	0.009	0.701	0.042	0.116	0.591	0.936	0.993
Male
rs3825199	G vs A	1.32 (1.06–1.64)	0.014	0.876	0.040	0.111	0.579	0.933	0.993
	AG vs AA	1.69 (1.23–2.31)	0.001	0.855	0.003	0.010	0.104	0.539	0.921
	AG-GG vs AA	1.61 (1.20–2.17)	0.002	0.923	0.006	0.017	0.159	0.656	0.950
	AA+AG+GG	1.31 (1.06–1.64)	0.015	0.881	0.059	0.159	0.675	0.954	0.995
rs11107116	T vs G	1.28 (1.03–1.59)	0.029	0.924	0.077	0.200	0.733	0.965	0.996
	GT vs GG	1.61 (1.18–2.20)	0.003	0.913	0.009	0.027	0.232	0.753	0.968
	GT-TT vs GG	1.54 (1.14–2.07)	0.004	0.958	0.013	0.038	0.304	0.815	0.978
	GG+GT+TT	1.28 (1.02–1.59)	0.030	0.924	0.077	0.200	0.733	0.965	0.996
rs10492321	A vs T	1.37 (1.10–1.70)	0.004	0.795	0.016	0.046	0.346	0.842	0.982
	TA vs TT	1.72 (1.25–2.37)	0.001	0.822	0.003	0.010	0.099	0.526	0.917
	TA-AA vs TT	1.69 (1.25–2.28)	0.001	0.865	0.002	0.006	0.064	0.407	0.873
	TT+TA+AA	1.37 (1.10–1.69)	0.005	0.801	0.012	0.036	0.289	0.804	0.976
≤60 years
rs3825199	AG vs AA	1.99 (1.35–2.94)	0.001	0.510	0.003	0.010	0.096	0.518	0.915
	AG-GG vs AA	1.73 (1.20–2.49)	0.003	0.782	0.012	0.035	0.287	0.802	0.976
rs11107116	GT vs GG	1.78 (1.21–2.62)	0.003	0.723	0.014	0.041	0.322	0.827	0.980
	GT-TT vs GG	1.54 (1.08–2.21)	0.018	0.922	0.059	0.157	0.673	0.954	0.995
rs10492321	TA vs TT	1.86 (1.26–2.74)	0.002	0.643	0.008	0.023	0.206	0.724	0.963
	TA-AA vs TT	1.61 (1.12–2.30)	0.010	0.883	0.029	0.083	0.499	0.909	0.990
Non-smoker
rs3825199	AG vs AA	1.92 (1.25–2.94)	0.003	0.574	0.014	0.040	0.317	0.824	0.979
	AG-GG vs AA	1.64 (1.11–2.43)	0.013	0.839	0.047	0.128	0.617	0.942	0.994
rs11107116	GT vs GG	1.80 (1.18–2.76)	0.006	0.685	0.030	0.085	0.504	0.911	0.990
	GT-TT vs GG	1.57 (1.06–2.32)	0.024	0.888	0.074	0.193	0.724	0.964	0.996
rs10492321	TA vs TT	1.77 (1.16–2.71)	0.008	0.713	0.035	0.098	0.544	0.923	0.992
	TA-AA vs TT	1.62 (1.09–2.40)	0.016	0.853	0.054	0.145	0.652	0.950	0.995
Alcohol drinker
rs10859525	G vs A	0.63 (0.42–0.96)	0.030	0.859	0.099	0.249	0.784	0.973	0.997
	AA+AG+GG	0.65 (0.43–0.98)	0.041	0.895	0.118	0.286	0.815	0.978	0.998
rs3825199	AG vs AA	1.87 (1.04–3.35)	0.037	0.589	0.153	0.351	0.856	0.984	0.998
Not alcohol drinker
rs3825199	AG vs AA	1.70 (1.12–2.59)	0.014	0.775	0.050	0.136	0.633	0.946	0.994
	AG-GG vs AA	1.52 (1.03–2.25)	0.035	0.915	0.107	0.264	0.798	0.975	0.997
rs11107116	GT vs GG	1.61 (1.06–2.44)	0.026	0.843	0.069	0.183	0.711	0.961	0.996
rs10492321	TA vs TT	1.67 (1.10–2.54)	0.016	0.800	0.058	0.157	0.672	0.954	0.995
	TA-AA vs TT	1.57 (1.06–2.33)	0.023	0.885	0.078	0.203	0.738	0.966	0.996
BMI >24 kg/m2
rs10859563	C vs G	0.70 (0.53–0.92)	0.011	0.637	0.047	0.130	0.621	0.943	0.994
	CC vs GG	0.46 (0.26–0.81)	0.008	0.386	0.053	0.143	0.647	0.949	0.995
	CC vs GG-GC	0.53 (0.32–0.87)	0.013	0.591	0.058	0.155	0.669	0.953	0.995
	GG+GC+CC	0.69 (0.52–0.92)	0.010	0.593	0.055	0.148	0.657	0.951	0.995
BMI ≤24 kg/m2
rs3825199	AG vs AA	1.66 (1.03–2.68)	0.037	0.777	0.128	0.306	0.829	0.980	0.998
rs11107116	GT vs GG	1.64 (1.02–2.64)	0.042	0.793	0.136	0.321	0.839	0.981	0.998
Diabetic nephropathy
rs10859525	G vs A	0.68 (0.50–0.94)	0.017	0.548	0.097	0.243	0.780	0.973	0.997
	AA+AG+GG	0.71 (0.51–0.99)	0.040	0.645	0.168	0.378	0.870	0.985	0.999
rs10859563	C vs G	0.72 (0.55–0.96)	0.022	0.700	0.098	0.245	0.781	0.973	0.997
	CC vs GG	0.51 (0.28–0.91)	0.024	0.527	0.114	0.279	0.810	0.977	0.998
	GC-CC vs GG	0.61 (0.40–0.91)	0.016	0.835	0.053	0.143	0.647	0.949	0.995
	GG+GC+CC	0.70 (0.53–0.93)	0.013	0.632	0.062	0.165	0.685	0.956	0.995
Diabetic retinopathy
rs10859525	G vs A	0.63 (0.41–0.99)	0.042	0.842	0.138	0.325	0.841	0.982	0.998
	AG vs AA	0.53 (0.29–0.95)	0.034	0.578	0.146	0.339	0.850	0.983	0.998
	AG-GG vs AA	0.53 (0.31–0.92)	0.025	0.582	0.110	0.271	0.804	0.976	0.998
	AA+AG+GG	0.63 (0.40–0.98)	0.042	0.847	0.125	0.300	0.825	0.979	0.998
T2DM patients with CHD
rs3825199	GG vs AA	0.35 (0.13–0.93)	0.035	0.237	0.308	0.572	0.936	0.993	0.999
	GG vs AA-AG	0.31 (0.12–0.79)	0.014	0.158	0.211	0.446	0.898	0.989	0.999
rs11107116	TT vs GG	0.28 (0.10–0.82)	0.020	0.145	0.295	0.557	0.932	0.993	0.999
	TT vs GG-GT	0.25 (0.09–0.71)	0.009	0.097	0.223	0.463	0.905	0.990	0.999
rs10859563	C vs G	0.70 (0.53–0.93)	0.015	0.632	0.062	0.165	0.685	0.956	0.995
	CC vs GG	0.48 (0.25–0.89)	0.020	0.448	0.117	0.284	0.814	0.978	0.998
	GG+GC+CC	0.70 (0.52–0.94)	0.018	0.627	0.078	0.203	0.737	0.966	0.996
Males
rs3825199|rs11107116|rs10492321	GTA	1.29 (1.03–1.60)	0.026	0.915	0.063	0.168	0.689	0.957	0.996
rs3825199|rs11107116|rs10492321	AGT	1.34 (1.08–1.66)	0.008	0.849	0.025	0.073	0.463	0.897	0.989

Notes: p values were calculated by logistic regression analysis with adjustments for age. Statistical power was calculated using the number of observations in the subgroup and the OR and p values in this table. The level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented. Bold values indicate that prior probability< 0.2 indicates noteworthy findings.

Abbreviations: T2DM, type 2 diabetes mellitus; SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; BMI, body mass index; CHD, coronary heart disease.