Table 3.
Brain-Derived Neurotrophic Factor in Cerebrospinal Fluid Samples without Blood (Grade 0)
| BDNF (pg/mL), (Mean, SEM) [n] | P-value | |||
|---|---|---|---|---|
| Group C | Group S | Group T | ||
| Whole group | ||||
| POD 1 | 9.3 (1.2) [22] | 11.1 (0.5) [24] | 16.8 (2.2) [28]*† | 0.005 |
| POD 7 | 10.2 (1.4) [27] | 10.8 (1.4) [28] | 13.4 (0.9) [27] | 0.368 |
| POD 14 | 6.2 (1.1) [24] | 10.0 (2.3) [25] | 9.6 (1.6) [28] | 0.252 |
| Subgroup | ||||
| POD 1 | 7.1 (1.3) [11] | 7.7 (1.5) [8] | 16.3 (6.1) [4]* † | 0.050 |
| POD 7 | 9.3 (1.5) [14] | 11.2 (0.1) [11] | 11.7 (2.5) [5] | 0.638 |
| POD 14 | 4.5 (0.7) [12] | 11.7 (0.1) [9] | 4.7 (0.2) [4] | 0.2877 |
Notes: *p < 0.05 as compared to the control. †p < 0.05 compared to sham. Bold text; statistically significant data.
Abbreviations: BDNF, brain-derived neurotrophic factor; SEM, standard error of the mean; POD, postoperative day; TBI, traumatic brain injury; NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; CSF, cerebrospinal fluid; Group C, a control group; Group S, a sham group; Group T, a TBI group; CCI, controlled cortical impact; POD, postoperative day; SEM, standard error of the mean; r, Spearman correlation coefficient.