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. 2022 Jan 21;20(1):e3001523. doi: 10.1371/journal.pbio.3001523

Fig 4. Distribution of TolC-like proteins.

Fig 4

(A) Phylogenetic tree of 416 TolC-like proteins (S1 Data) from across the range of bacterial Phyla. The archetypal E. coli TolC (accession: P02930) is indicated with an orange arrow. (B) Cladogram of 12 TolC-like proteins found within 5 different families of monoderm Firmicutes. Protein ID is shown alongside the species’ name. Presence of proven or putative SLPs is indicated by a yellow square. Endospore-forming ability (green circle) or inability (red circle) is also indicated. (C) Architecture of a TolC-dependent efflux pump in monoderm Firmicutes. CW, cell wall (i.e., peptidoglycan and S-layer); CM, cytoplasmic membrane; SLP, S-layer protein.