Table 1. The 20 biosets with the highest correlation to the NF-κB biomarker.

Bioset Name	Chemical	Cell type	Public ID	Time of exposure (hrs)	Conc (in uM unless otherwise indicated)	NF-κB biomarker (-Log(p-value))
Dermal fibroblasts (C18)—3uM sphingosine-1-phosphate treated 4hr _vs_ untreated_GPL6480	Sphingosine 1-phosphate	Dermal fibroblasts	GSE56308	4	3	15.9
Dermal fibroblasts (NHDF)—3uM sphingosine-1-phosphate treated 4hr _vs_ untreated_GPL6480	Sphingosine 1-phosphate	Dermal fibroblasts	GSE56308	4	3	15.7
Lung cancer A549 cell line + Nilotinib 30000nM for 4hr _vs_ control	Nilotinib	A549	E-TABM-585	4	30	15.6
Primary mesothelial HPM3 cells, pleural + 5ug/cm2 crocidolite asbestos for 8hr _vs_ unexposed	Asbestos, crocidolite	HPM3	GSE63966	8	5ug/cm2	15.2
Paroxetine_20uM_24hr_Chen	Paroxetine	MCF7	PMID: 24496634	24	20	13.3
Macrophages monocyte-derived 10uM nutlin-3 treated 2hr _vs_ DMSO	Nutlin 3	Monocyte-derived macrophages	GSE43596	2	10	13.2
Dermal fibroblasts (C18)—3uM sphingosine-1-phosphate treated 8hr _vs_ untreated_GPL6480	Sphingosine 1-phosphate	Dermal fibroblasts	GSE56308	8	3	13.2
HUVEC cells + 1.5 mM nickel chloride for 5hr _vs_ control	Nickel chloride	HUVEC	GSE4852	5	1500	12.6
Bronchial epithelial BEAS-2B cells treated 4hr with 10ug/ml PM10—indoor _vs_ outdoor	Particulate matter	BEAS-2B	GSE34607	4	10ug/ml	12.2
Huh7 hepatocarcinoma cells 10uM GENK treated for 4hr _vs_ DMSO control	Genkwanin	HuH-7	GSE39002	4	10	12.2
A549 lung carcinoma cells grown in presence of 10nM geldanamycin (IC20) 48hr _vs_ vehicle	Geldanamycin	A549	GSE26525	48	0.01	12.2
Monocyte derived dendritic cells + TLR4 agonist R848 2hr _vs_ untreated	R848	Monocyte-derived dendridic cells	GSE2706	2	2.5 μg/ml	11.8
HEK293 cells overexpression p65-S547A mutant—etoposide treated 8hr _vs_ untreated	Etoposide	HEK293	GSE33990	8	Not reported	11.5
Bronchial epithelial BEAS-2B cells—4hr 10ug/ml indoor PM10 _vs_ 4hr untreated	Particulate matter	BEAS-2B	GSE34607	4	10ug/ml	11.4
Dermal fibroblasts (NHDF)—3uM sphingosine-1-phosphate treated 8hr _vs_ untreated_GPL6480	Sphingosine 1-phosphate	Dermal fibroblasts	GSE56308	8	3	11.3
Dermal fibroblasts (NHDF)—3uM sphingosine-1-phosphate treated 12hr _vs_ untreated_GPL6480	Sphingosine 1-phosphate	Dermal fibroblasts	GSE56308	12	3	11.1
Macrophages treated 6hr with 10ug curdlan _vs_ untreated controls	Curdlan	Macrophage	GSE32282	6	10ug/ml	10.8
Hepatocellular carcinoma hepatocyte HepaRG cells + 6hr 100nM vinblastine _vs_ DMSO	Vinblastine	HepaRG	GSE69851	6	100	10.4
Lung epithelium A549 cells 200ug/ml silica treated from 24hr _vs_ untreated	Silicon dioxide	A549	GSE30215	24	0.1	10.4
HL60 cells + amphotericin B, 4.4uM _vs_ DMSO vehicle	Amphotericin B	HL-60	GSE5258	6	4.4	10.3