Table 3.
Univariate and multivariate Cox analyses for progression-free and overall survival
| Univariate analysis for PFS (n=328) |
Multivariate analysis for PFS (n=328) |
||||||
|---|---|---|---|---|---|---|---|
| Variable | Median (Months) |
95% CI | p value | HR | 95% CI | p value | |
| Whole population | 3.3 | [2.5-4.1] | - | - | |||
| Performance status (ECOG) | ≤ 1 | 3.6 | [2.9-4.3] | <0.0001 | 0.4 | [0.3-0.6] | <0.0001 |
| > 1 | 1.6 | [1.1-2.1] | 1 | ||||
| Cancer Type | NSCLC | 4 | [2.3-5.7] | 0.003 | - | ||
| Other | 2.6 | [1.9-3.3] | |||||
| Previous lines of treatment | ≤ 1 | 3.9 | [2.9-4.8] | 0.003 | - | ||
| > 1 | 2.5 | [1.9-3.1] | |||||
| TPS score (%) | < 1 | 2.7 | [1.9-3.5] | <0.0001 | 1.7 | [1.3-2.5] | 0.001 |
| ≥ 1 | 7.0 | [1.4-12.6] | 1 | ||||
| CD8 density | Low density | 2.7 | [1.7-3.6] | 0.005 | - | ||
| High density | 3.7 | [1.9-5.4] | |||||
| Presence of mature TLS | No | 2.7 | [1.9-3.5] | 0.015 | 1.4 | [1.1-2.0] | 0.04 |
| Yes | 6.1 | [1.9-10.2] | 1 | ||||
| Univariate analysis for OS (n=328) | Multivariate analysis for OS (n=328) |
||||||
| Variable | Median (Months) |
95% CI | p value | HR | 95% CI | p value | |
| Whole population | 14.9 | [12.9-16.9] | - | - | |||
| Performance status | ≤ 1 | 15.6 | [12.9-18.3] | <0.0001 | 0.32 | [0.20-0.51] | <0.0001 |
| > 1 | 5 | [2.1-7.9] | 1 | ||||
| Cancer Type | NSCLC | 16.8 | [13-20.6] | 0.06 | - | ||
| Other | 12.9 | [10.7-15.1] | |||||
| TPS score (%) | < 1 | 13.1 | [10.8-15.4] | 0.07 | - | ||
| ≥ 1 | 16.9 | [12.8-20.9] | |||||
| CD8 density | Low | 13.1 | [10.2-15.9] | 0.18 | - | ||
| High | 14.9 | [11.9-17.9] | |||||
| Presence of mature TLS | No | 13.3 | [11.1-15.5] | 0.016 | 1.5 | [1.1-2.3] | 0.03 |
| Yes | 24.8 | [6.8-42.8] | 1 | ||||
*
Statistical test: Cox regression model