Figure 5.

Exosomal circ007293 promoted the malignant phenotype of PCT cells via the miR-653-5p/PAX6 axis. TPC-1 and KTC-1 cells transfected with miR-653-5p mimic or si-PAX6 were treated with oe-circ007293-exo or oe-NC-exo. (a) The viability of TPC-1 and KTC-1 cells was evaluated using CCK-8 assay. (b) The migration of TPC-1 and KTC-1 cells was analyzed using wound healing assay. Magnification: ×100; scale bar: 100 μM. (c) The invasion of TPC-1 and KTC-1 cells was analyzed using transwell assay. Magnification: ×200; scale bar: 50 μM. (d) The expression of E-cadherin, N-cadherin, and vimentin in TPC-1 and KTC-1 cells was determined by Western blot. ***p < 0.001 compared to the oe-NC-exo group; #p < 0.05 and ##p < 0.01 compared to the oe-circ007293-exo group