Figure 5.

Simvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via blocking HIF-1α by miR-19a-3p. (a) Cell proliferation was detected through CCK-8. (b) Cell apoptosis analysis was observed via Flow Cytometry. (c) The levels of apoptosis protein of Mcl-1, caspase-3 were performed by WB. (d-e) The migration and invasion were detected by wound healing assay and transwell separately. Statistical analysis: compared with simvastatin group, *P < 0.05, **P < 0.01. Compared with the simvastatin+si-HIF-1α group, ^#P < 0.05, ^##P < 0.01