Figure 4.

Fer-1 alleviated cardiac inflammatory response in septic rats. (a) Representative images of the morphological analysis and inflammatory cells infiltration as reflected by the H&E staining respectively of rats in four groups (n = 3 per group). (b-e) Representative western blots and statistical analysis of the TNF-α, IL-1β, and IL-6 protein levels in myocardium respectively of rats in four groups (n = 3 per group). (f-h) Representative enzyme-linked immunosorbent assay and statistical analysis of the serum TNF-α, IL-1β, and IL-6 levels respectively of rats in four groups (n = 3 per group). Data are expressed as mean ±SEM. *P < 0.05 vs. Control group, #P < 0.05 vs. LPS group

Abbreviations: Fer-1, Ferrostatin-1; TNF-α, Tumor necrosis factor-α; IL-1β, Interleukin-1; IL-6, Interleukin-6.