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. 2021 Dec 2;12(2):10363–10372. doi: 10.1080/21655979.2021.1996506

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — LINC00998 inhibits mTORC2 level. (a) The correlation between LINC00998 and mTORC2 mRNA in TCGA AML database. (b, c). The mRNA and protein levels of mTORC2 after LINC00998 overexpression. (d) qRT-PCR analysis of mTORC2 mRNA levels in PBMCs from 80 AML patients and 59 healthy controls. (e) The correlation between LINC00998 and mTORC2 mRNA in AML. F-H. Cell viability, colony and DNA synthesis in LINC00998-overexpressed U937 and THP-1 cells with mTORC2 overexpression. **P < 0.01, ***P < 0.001