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. 2021 Nov 27;12(2):10023–10036. doi: 10.1080/21655979.2021.1994721

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — METTL3 promoted EMT, cell invasion, and migration in ESCA cells. ECA109 and TE-1 cells were transfected with sh-METTL3 with sh-NC as the control. EMT, cell migration, and invasion were observed. A: METTL3 expression pattern in ECA109 and TE-1 cells was detected via qRT-PCR; B: Positive expression patterns of N-cadherin and E-cadherin were detected via immunofluorescence; C: Cell invasion and migration potentials were detected via Transwell assays; Cell experiment was conducted 3 times independently. All data were measurement data and represented as mean ± SD. Data in figures A and C were analyzed using one-way ANOVA and data in figure B were analyzed using two-way ANOVA. After analysis, data were verified by Tukey’s multiple comparison test. *** P < 0.001