Figure 2.

Inhibiting ITGA11 attenuated GC cell proliferation and invasion and strengthened apoptosis

ITGA11 knockdown models were constructed in MKN45 and AGS cells. A-B: qRT-PCR and WB were implemented to test the effect of ITGA11 knockdown plasmids. C-D: Cell proliferation was verified by CCK-8 and colony formation experiment. E-F: The migrative and invasive ability of MKN45 and AGS were monitored by Transwell assay. G: The profiles of Bcl-2, Bad, C-Caspase3 and Bax were monitored by WB. H: TUNEL assay was adopted to gauge the apoptosis of MKN45 and AGS cells. Ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001. N = 3