Table 4.
A summary of the diagnostic performance of in vivo confocal microscopy (IVCM) on infectious keratitis (IK).
| Author | Year | IVCM system | Sample size | Sensitivity | Specificity |
|---|---|---|---|---|---|
| Wang et al. [145] a | 2019 | HRT3/RCM | 49 | 66.7 (F); 91.7 (A); 66.7 (B); 100 (V) |
100 (F); 100 (A); 89.2 (B); 93.2 (V) |
| Goh et al.84 | 2018 | HRT2/RCM | 15 (A); 11 normal |
100 (A) | 100 (A) |
| Chidambaram et al. [146] | 2016 | HRT3/RCM | 176 (F) 17 (A) |
85.7 (F); 88.2 (A) |
81.4 (F); 98.1 (A) |
| Vaddavalli et al. [147] | 2011 | Nidek ConfoScan 3.0 | 93 (F); 10 (A) |
89.2 (F); 80.0 (A) |
92.7 (F); 100 (A) |
| Hau et al. [148] b | 2010 | HRT2/RCM | 15 (F); 26 (A); 21 (B) |
27.9–55.8 | 42.1–84.2 |
| Kanavi et al. [149] | 2007 | Nidek ConfoScan 3.0 | 16 (F); 15 (A) |
94.0 (F); 100 (A) |
78.0 (F); 84.0 (A) |
HRT/RCM = Heidelberg Retinal Tomography (version 2 or 3) with Rostock Corneal Module.
F = Fungi; A = Acanthamoeba; B = Bacteria; V = Viruses.
a
This study included all types of IK, including bacterial, fungal, Acanthamoeba, viral and polymicrobial infection.
b
This study included bacterial, fungal and Acanthamoeba infection.