Figure 2.

SERPINC1 is targeted by miR-200c-3p

(a) TargetScan database predicted five miRNAs potentially harboring conserved binding sites for SERPINC 3ʹUTR. (b) Candidate miRNA expression levels were tested using RT-qPCR in control or thrombotic group. n = 6. (c) Binding sequence of miR-200 c-3p on SERPINC1 3ʹUTR is obtained from TargetScan database. (d) Luciferase reporter assay was conducted to assess the binding ability of miR-200 c-3p and SERPINC1 3ʹUTR. **p < 0.01. miR-NC: miRNA inhibitor negative control; Wt: wild-type; Mut: mutant.