Figure 1.

The human DBL family and DOCK family of Rho GEFs. (a) The 70 members of DBL family Rho GEFs and (b) 11 members of DOCK family Rho GEFs are arranged in phylogenetic tree by MEGA7.0 software, using the protein sequences obtained from UniProt. The protein domain architecture is visualized by Evolview. Each color represents one distinct structural domain. The DH, PH domains of DBL Rho GEF family and DHR-1, DHR2 domains of DOCK Rho GEF family with the corresponding colors are highlighted in the left panel. All proteins are visualized in the same scale except OBSCN. For other structural domains, please refer to FigureS1. DH: Dbl homology; PH: Pleckstrin homology; DHR-1: DOCK homology region 1; DHR-2: DOCK homology region