Figure 2.

MiR-191-5p overexpression alleviates Aβ1-42-induced microglial cell injury. (a) MiR-191-5p expression in microglia treated with or without Aβ1-42, treated with Aβ1-42 and transfected with NC mimics, treated with Aβ1-42 and transfected with miR-191-5p mimics was measured by RT-qPCR. (b) Viability of microglial cells in the above four groups (Con, Aβ1-42, Aβ1-42+ NC mimics, Aβ1-42+ miR-191-5p) was assessed by CCK-8 assays. (c-d) Apoptosis of microglial cells in the above four groups was detected by flow cytometry analyses. (e-f) Western blotting was performed to assess protein levels of BACE1 and Tau-5 in microglial cells in the above four groups. *p < 0.05, **p < 0.01, ***p < 0.001