Table 3.
| Protein | A-ring | B-ring | C-ring | |
|---|---|---|---|---|
| IL1B | Hydrophobic interaction | Leu80 | ||
| π-sigma interaction | Thr79 | |||
| hydrogen bonding interaction | Pro78 | |||
| JUN | hydrophobic interaction | Val158 and Ile32 | Val158, Ile32, Ala53, Val40 | Val40, Leu168 and Lys55 |
| hydrogen bonding interaction | Carbonyl B-ring with Leu110 | Lys55 | ||
| MAPK3 | hydrophobic interaction | Val56 | ||
| hydrogen bonding interaction | Asp123 and Met125 | Lys71 | ||
| MMP9 | π-π ring stacking effect | Tyr248 | Phe250 | Phe250 |
| hydrogen bonding interaction | Tyr248 and Arg249 | Gly215 and Lys214 | ||
| PTGS2 | π-cationic interaction | His386 | His207 | His207 |
| hydrogen bonding interaction | Asn382 | Thr206 | Ala202 | |
| π-π ring stacking effect | His388 | |||
| amide-π stacking effect | Ala202 | |||
| TNF | π-π ring stacking effect | Tyr119 | Tyr119 | Tyr119 |
| hydrogen bonding interaction | Tyr151 and Ser60 | Gln61 |