Table 5.
Risk factors associated with all-cause 28d-ICU mortality in patients with severe COVID-19 and ARDS according to univariate logistic regression analysis.
| Risk factors | OR | 95% CI | P-value |
|---|---|---|---|
| Age (years) | 1.012 | 0.970–1.057 | 0.573 |
| Murray LIS | 1.365 | 0.314–5.927 | 0.678 |
| ICU admission | |||
| White blood cell count (× 109/L) | 1.035 | 0.947–1.131 | 0.447 |
| Leukocyte count (× 109/L) | 0.597 | 0.131–2.710 | 0.504 |
| Platelets count (× 109/L) | 0.997 | 0.990–1.004 | 0.360 |
| Prothrombin time (s) | 0.975 | 0.812–1.172 | 0.790 |
| d-dimer (mg/L) | 1.000 | 1.000–1.000 | 0.307 |
| Hypersensitive troponin I (pg/mL) | 0.999 | 0.997–1.001 | 0.290 |
| Creatine kinase-MB (U/L) | 1.016 | 0.994–1.038 | 0.159 |
| Lactate dehydrogenase (U/L) | 1.002 | 0.999–1.005 | 0.259 |
| Alanine aminotransferase (U/L) | 1.003 | 0.996–1.010 | 0.338 |
| Aspartate aminotransferase (U/L) | 1.002 | 0.997–1.007 | 0.363 |
| Bilirubin (μmol/L) | 1.050 | 0.989–1.115 | 0.108 |
| After intubation | |||
| White blood cell count (× 109/L) | 1.047 | 0.950–1.154 | 0.353 |
| Leukocyte count (× 109/L) | 0.373 | 0.092–0.151 | 0.167 |
| Platelets count (× 109/L) | 0.994 | 0.986–1.002 | 0.144 |
| Prothrombin time (s) | 01.288 | 0.947–1.752 | 0.106 |
| Hypersensitive troponin I (pg/mL) | 0.999 | 0.997–1.001 | 0.174 |
| Bilirubin (μmol/L) | 1.060 | 0.994–1.129 | 0.076 |
| Acute cardiac injury | 1.442 | 0.439–4.741 | 0.546 |
| Arrhythmia | 1.083 | 0.330–3.561 | 0.895 |
| AKI | 1.145 | 0.337–3.891 | 0.828 |
| Glucocorticoid therapy | 1.364 | 0.294–6.319 | 0.692 |
| Interval between hospital admission and mechanical ventilation (days) | 1.051 | 0.973–1.136 | 0.209 |
| Total length of HFNC + NIV before IMV (days) | 0.999 | 0.994–1.004 | 0.604 |
| Respiratory support decision score | |||
| Code C | 0.212 | 0.059–0.760 | 0.017 |
| Code H | 0.136 | 0.036–0.517 | 0.003 |
| Code I | 0.214 | 0.059–0.775 | 0.019 |
| Code J | 0.212 | 0.059–0.760 | 0.017 |
| Code N | 0.125 | 0.024–0.648 | 0.013 |
| Code O | 0.255 | 0.073–0.891 | 0.032 |
| Code P | 0.174 | 0.045–0.665 | 0.011 |
| Code R | 3.680 | 0.962–14.075 | 0.057 |
| Code S | 5.000 | 0.852–29.349 | 0.075 |
| Total decision score | 0.763 | 0.640–0.909 | 0.002 |
28 d-ICU: 28-day mortality after ICU admission; AKI: Acute kidney injury; ARDS: Acute respiratory distress syndrome; CI: Confidence interval; COVID-19: Coronavirus disease 2019; HFNC: High-flow nasal cannula; ICU: Intensive care unit; IMV: Invasive mechanical ventilation; LIS: Lung injury score; NIV: Non-invasive ventilation; OR: Odds ratio.