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. 2022 Feb 3;3(3):188–203.e4. doi: 10.1016/j.medj.2022.01.004

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Pharmacokinetics and biodistribution of ADM03820

(A) Schema of study design. Different doses of antibody combination ADM03820 (containing COV2-2130-YTE-LALA and COV2-2381-YTE-LALA at a 1:1 ratio) were administered to cynomolgus macaques (n = 3 per group) by IV (11.7 or 31.3 mg/kg) or IM (11.7 or 31.3 mg/kg) route. Human antibody concentration was assessed by ELISA in (B) serum, (C) BAL, or (D) nasal swab eluate samples at indicated time points after ADM03820 administration. The dotted horizontal line depicts the assay limit of detection.