Table 1.
Neutralization breadth of ADM03820 against SARS-CoV-2 variants of concerna (IC50 [ng/mL] against indicated virus)b
| WA1/2020 | D614G | B.1.1.7 (alpha) | Wash-B.1.351 (beta) | B.1.617.2 (delta) | Wash-B.1.1.28 (gamma) |
|---|---|---|---|---|---|
| 28 | 21 | 20 | 19 | 25 | 8 |
a
Neutralizing activity of ADM03820 against authentic SARS-CoV-2 WA1/2020, authentic SARS-CoV-2 WA1/2020 bearing D614G mutation, or authentic B.1.1.7, authentic B.1.617.2, chimeric Wash-B.1.351, and chimeric Wash-B.1.1.28 viruses was assessed using a focus reduction neutralization test (FRNT).
b
Half-maximal inhibitory concentration (IC50) values are shown and represent the average of technical duplicates and two independent experiments.