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. 2022 Jan 20;11:811941. doi: 10.3389/fonc.2021.811941

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Copyright © 2022 Srivastava, Sharma, Khanna, Sadhu Balasundaram, Chowdhury, Chowdhury and Mukherjee

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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p65 activation enhances proliferation co-operatively with STAT-3. (A) Immunoblot showing expression of p65 after IL-6 treatment for 72 h. (B) Immunofluorescence image and relative fluorescence intensity of p65 in untreated and IL-6-treated cells (scale bar: 10 μm). The white arrow indicates p65. (C) Immunoblot showing expression of p65 in IL-6-treated or IL-6 plus p65-siRNA treated cells after 72 h of exposure. (D) Graph representing a shift in PI fluorescence in IL-6-treated or IL-6 plus p65-siRNA treated cells after 72 h. (E) Immunoblot showing expression of PCNA in IL-6-treated or IL-6 plus p65-siRNA treated cells after 72 h of treatment. (F) (i) Immunoblot showing expression of STAT-3 in IL-6-treated or IL-6 plus p65-siRNA treated cells after 72 h (ii) Immunoblot showing expression of STAT-3, p65, and PCNA in IL-6-treated or IL-6 plus Stattic exposed cells. (G) Co-immunoprecipitation analysis of STAT-3 with p65 after IL-6 exposure for 72 h The proteins were immunoprecipitated with anti-STAT-3 antibody and then probed with p65. *, *** and **** refers to p value significance of ≤0.1, ≤0.001 & ≤ 0.0001 respectively.