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. 2021 Dec 8;13(3):925–947. doi: 10.1016/j.jcmgh.2021.12.002

Figure 1.

Figure 1

Hepatic S1pr4 expression is uniquely increased in the liver of murine NASH models. (A) Diet was administered to mice for 12 weeks for HFHCD, 8 weeks for MCDD, 16 weeks for WD, and 6 weeks for CDA+HFD. (A) Hepatic S1pr mRNA expression in HFHCD-, MCDD-, WD-, and CDA+HFD–induced dietary models of NASH (n = 6). (B) Hepatic mRNA expression levels of S1PR4 in the liver samples of patients with NASH/cirrhosis undergoing liver transplantation (n = 9). Surgical specimens of the donor livers were used as controls (n = 10). All data are shown as means ± SEM. Data were analyzed by Student two-tailed unpaired t test. ∗P < .05, ∗∗P < .01, ∗∗∗P < .001, and ∗∗∗∗P < .0001. CON, control; Rel., relative.