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In vitro characterization of implants
(A) Cy5.5/PLGA implants used in this specific use case.
(B) In vitro release profile of Cy5.5 from implant (data displayed as mean ± SEM; n = 3) in PBS supplemented with bovine serum albumin (0.1%, w/v) over 7 days reveals the sustained drug release. At 1 week, 0.6 ng of dye was detected in the buffer, for a cumulative release percentage of 3.4% (based on initial calculation of 18 ng Cy5.5 in intact implant). See also Figure S1.
