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. 2021 Dec 30;57:101428. doi: 10.1016/j.molmet.2021.101428

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Crown Copyright © 2021 Published by Elsevier GmbH.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure S3 — Effects of CD36 on liver SREBP2 activation. A: The mRNA levels of Srebp2 and downstream targets Hmgcr and Ldlr in HFD-fed fl/fl and LKO mice were analyzed by Q-PCR (B). n=8, ∗P < 0.05 vs. fl/fl mice. B: The hepatic expression of SREBP2 and downstream target HMGCR in HFD-fed fl/fl and LKO mice were analyzed by immunoblotting. Quantitation of protein levels was shown in the right. n=3, ∗P < 0.05 vs. fl/fl mice. C: The expression of SREBP2 and downstream target HMGCR in primary hepatocytes from fl/fl and LKO mice were analyzed by immunoblotting. Quantitation of protein levels was shown in the right. n=3, ∗P < 0.05 vs. fl/fl mice. E: The protein levels of SREBP2 of cytoplasmic and nuclear fractions from NC and CD36OE cells were analyzed by immunoblotting.