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. Author manuscript; available in PMC: 2022 Feb 3.
Published in final edited form as: J Am Acad Dermatol. 2021 Sep 20;86(2):399–405. doi: 10.1016/j.jaad.2021.09.018

Table 2:

SEP-atopic dermatitis associations by study characteristic

Positive Association Negative Association No Association Inconclusive Results Total
37 (42%) 13 (15%) 23 (26%) 15 (17%) 88
Region
Africa/Middle East 3 (25%) 2 (17%) 3 (25%) 4 (33%) 12
Asia 10 (45%) 5 (23%) 4 (18%) 3 (14%) 22
Europe 22 (51%) 2 (5%) 14 (32%) 5 (12%) 43
Americas 2 (20%) 4 (40%) 1 (10%) 3 (30%) 10
Oceania 0 0 1 (100%) 0 1
Study Design
Case-Control 3 (43%) 1 (14%) 2 (29%) 1 (14%) 7
Cohort 9 (41%) 3 (14%) 8 (36%) 2 (9%) 22
Cross-Sectional 25 (43%) 9 (15%) 13 (22%) 12 (20%) 59
Age Group
Adults 3 (30%) 1 (10%) 3 (30%) 3 (30%) 10
Both 3 (30%) 3 (30%) 3 (30%) 1 (10%) 10
Children 31 (46%) 9 (13%) 17 (25%) 11 (16%) 68
Method of Atopic Dermatitis Assessment
Exam 2 (22%) 1 (11%) 4 (45%) 2 (22%) 9
Self-Report 31 (46%) 9 (14%) 15 (22%) 12 (18%) 67
Medical Record 4 (33%) 3 (25%) 4 (33%) 1 (9%) 12
Sample Size
20000+ 14 (46%) 6 (19%) 3 (12%) 6 (23%) 29
2500–19999 15 (50%) 2 (7%) 9 (30%) 4 (13%) 30
105–2499 8 (28%) 5 (17%) 11 (38%) 5 (17%) 29
Publication Date
1975–1989 3 (43%) 0 0 4 (57%) 7
1990–1999 7 (88%) 0 0 1 (12%) 8
2000–2009 11 (46%) 2 (8%) 4 (17%) 7 (29%) 24
2010–2019 16 (33%) 14 (29%) 10 (20%) 9 (18%) 49