Table 3.

TRAEs.

	Arm A (N = 8)			Arm B (N = 24)			Arm C (N = 14)			Arm D (N = 30)			Overall (N = 76)
	Grade 1/2	Grade 3	Total	Grade 1/2	Grade 3	Total	Grade 1/2	Grade 3	Total	Grade 1/2	Grade 3	Total	Total
Fatigue	3 (37.5)	1 (12.5)	4 (50.0)	10 (41.7)	7 (29.2)	17 (70.8)	8 (57.1)	2 (14.3)	10 (71.4)	14 (46.6)	1 (3.3)	15 (50.0)	46 (60.5)
Nausea	6 (75.0)	0	6 (75.0)	9 (37.5)	1 (4.2)	10 (41.7)	9 (64.3)	0	9 (64.3)	20 (66.7)	0	20 (66.7)	45 (59.2)
Decreased appetite	4 (50.0)	0	4 (50.0)	11 (45.8)	0	11 (45.8)	10 (71.5)	0	10 (71.5)	8 (26.7)	0	8 (26.7)	33 (43.4)
Thrombocytopenia	5 (62.5)	1 (12.5)	6 (75.0)	14 (58.3)	2 (8.3)	16 (66.7)	4 (28.6)	0	4 (28.6)	6 (20.0)	1 (3.3)	7 (23.3)	33 (43.4)
Vomiting	1 (12.5)	0	1 (12.5)	7 (29.2)	0	7 (29.2)	5 (35.7)	0	5 (35.7)	10 (33.3)	0	10 (33.3)	23 (30.3)
Leukopenia	0	0	0	5 (20.8)	2 (8.3)	7 (29.2)	0	1 (7.1)	1 (7.1)	12 (40.0)	1 (3.3)	13 (43.3)	21 (27.6)
Dysgeusia	1 (12.5)	0	1 (12.5)	9 (37.5)	0	9 (37.5)	6 (42.9)	0	6 (42.9)	4 (13.3)	0	4 (13.3)	20 (26.3)
Neutropenia	1 (12.5)	0	1 (12.5)	3 (12.5)	4 (16.7)	7 (29.2)	0	2 (14.3)	2 (14.3)	8 (26.7)	2 (6.7)	10 (33.3)	20 (26.3)
Hyponatremia	2 (25.0)	0	2 (25.0)	9 (37.5)	1 (4.2)	10 (41.7)	2 (14.3)	0	2 (14.3)	1 (3.3)	0	1 (3.3)	15 (19.7)
Anemia	1 (12.5)	0	1 (12.5)	5 (20.8)	0	5 (20.8)	1 (7.1)	0	1 (7.1)	6 (20.0)	0	6 (20.0)	13 (17.1)
Weight decrease	1 (12.5)	0	1 (12.5)	4 (16.7)	0	4 (16.7)	5 (35.7)	1 (7.1)	6 (42.9)	2 (6.7)	0	2 (6.7)	13 (17.1)
Constipation	0	0	0	2 (8.3)	0	2 (8.3)	4 (28.6)	0	4 (28.6)	5 (16.7)	0	5 (16.7)	11 (14.5)
Blurred vision	0	0	0	5 (20.8)	0	5 (20.8)	1 (7.1)	0	1 (7.1)	2 (6.7)	0	2 (6.7)	8 (10.5)
Diarrhea	1 (12.5)	1 (12.5)	2 (25.0)	3 (12.5)	0	3 (12.5)	0	0	0	4 (13.3)	0	4 (13.3)	9 (11.8)
Lymphopenia	0	2 (25.0)	2 (25.0)	1 (4.2)	1 (4.2)	2 (8.3)	0	0	0	0	3 (10.0)	4 (13.3)	8 (10.5)