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. 2022 Jan 20;9:801468. doi: 10.3389/fcell.2021.801468

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Copyright © 2022 Luo and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the germ cell development and reconstitution of mPGCLCs and hPGCLCs in vitro. The center is the image shows developmental stages and the timeline of mouse and human germ cell development. PGCs undergo specification, migration, sex determination, and meiosis or mitotic arrest before birth. The upper and lower panels show the induction of mPGCLCs and hPGCLCs.