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. 2022 Jan 20;9:808905. doi: 10.3389/fcell.2021.808905

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Copyright © 2022 Sun, Gu, Xu, Zhao, Zhou, Zhou, Zhang, Wang, Han, Chai and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UC-MSCs modulated the composition of gut microbiota in MPTP-induced PD mice. (A) Rarefaction curves of samples; (B) alpha diversity presented by Chao-1 index; (C) PCoA analysis of samples; (D) histogram based on relative abundance at phylum level; (E) average relative abundance of the microbial community for each group at the genus level. (F,G) Comparison of gut microbiota using LES among the NS-PBS, NS-MSC, MPTP-PBS, and MPTP-MSC groups at the OUT level. Cladogram (F) and histogram (G) of bacterial taxa that significantly differed among the three groups (LDA >4.0 and p < 0.05). Blue, green, red, or shading in the cladogram depicts bacterial taxa that were significantly higher in the NS-PBS, MPTP-PBS, or MPTP-MSC groups, n = 12 per group. *p < 0.05, **p < 0.01 compared with the MPTP-PBS group.