Skip to main content
. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Cell Physiol. 2021 Sep 13;237(1):983–991. doi: 10.1002/jcp.30574

Figure 2. Myeloid PTEN deficiency aggravates kidney injury and fibrosis.

Figure 2.

A, Representative photomicrographs of PAS-stained kidney sections showing AngII-induced kidney damage in LysMCre−PTENf//f and LysMCre+PTENf//f mice. Scale bar, 20 μm. B, Quantitative assessment of renal injury in LysMCre−PTENf//f and LysMCre+PTENf//f mice. *P<0.01 vs LysMCre−PTENf//f-Vehicle, + P<0.01 vs LysMCre+PTENf//f-AngII, # P<0.01 vs LysMCre−PTENf//f-AngII. n=6 per group. C, Representative photomicrographs of kidney sections stained with sirius red for assessment of total collagen deposition in the kidney 4 weeks after Ang II or vehicle treatment. Scale bar, 20 μm. D, Quantitative analysis of interstitial collagen content in the kidney of LysMCre−PTENf//f and LysMCre+PTENf//f mice. *P<0.01 vs LysMCre−PTENf//f-Vehicle; +P<0.01 vs LysMCre+PTENf//f-AngII; and #P<0.01 vs LysMCre+PTENf//f-AngII. n=6 per group.