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. Author manuscript; available in PMC: 2022 Dec 16.
Published in final edited form as: Drug Resist Updat. 2021 Dec 16;59:100796. doi: 10.1016/j.drup.2021.100796

Figure 1.

Figure 1

The role of heterogeneity in drug resistance. An example of cells in the tissue containing a vast number of common driver mutant (e.g., KRas4B G12C) and a small number of rare drug resistance mutant cells (lower left). When a drug is taken, all cells are decimated except those with rare resistance mutation for the particular drug, resulting that those cells with the rare mutation proliferate (middle). A subsequent drug will remove the rare drug resistance mutant cells in later stage of chemotherapy (lower right). However, simultaneously taking both drugs have a better chance of success.