Table 2.

Significant (p<5 × 10⁻⁸) previously unreported secondary signals at known fasting insulin and fasting glucose loci

Trait	Secondary Varianta	Chr:Position	Ref allele	Alt allele	Locus	Effect (SE) of alt allele in conditional analysis	Primary analysis transethnic p valueb	Conditional analysis transethnic p valuec	Primary conditioning variant(s)d	LD D’e	LD r2f	MAF
												Transethnic	AA	EA	HA	ASN	HI	NAm
Fasting insulin	rs330941	8:9018657	C	T	PPP1R3B	0.045 (0.007)	4.79×10−7	2.37×10−10	rs4841132	0.18	0.005	0.43	0.29	0.39	0.49	0.22	0.27	0.43
Fasting glucose	rs55908146	7:44180226	G	A	GCK/MYL7	0.043 (0.008)	8.03×10−6	1.75×10−8	rs2908286, rs2908290	0.04, 0.24	0.001, 0.014	0.28	0.15	0.32	0.30	0.26	0.25	0.30

^aLead variant from conditional analysis reaching locus-specific significance

^bp value of the secondary variant in the primary GWAS analysis, not adjusted for the primary variant

^cp value of the secondary variant, adjusted for the primary variant(s)

^dLead variant(s) from the primary analysis and previous stepwise conditional analysis

^eLD D′ between primary variant(s) and secondary variant in PAGE Study data (transethnic LD generated from unrelated subset of AA, HA, ASN, HI and NAm participants)

^fLD r² between primary variant(s) and secondary variant in PAGE Study data (transethnic LD generated from unrelated subset of AA, HA, ASN, HI and NAm participants)