Table 1.

Baseline Characteristics of NOA-Status Patient Groups (N = 221 Patient Admissions)

	No NOA (N = 81)	NOA-Abnormal (N = 61)	NOA-Normal (N = 79)	Global p	NOA-Abnormal p	NOA-Normal p
Demographics Mean [25%, 75%]/N (%)
Age	60.8 [53.0, 70.0]	57.0 [44.0, 67.0]	55.6 [46.5, 66.0]	0.09	0.18	0.03*
Female	29 (35.8)	27 (44.3)	34 (43.3)	0.54	0.31	0.35
White Race	60 (74.1)	32 (52.4)	61 (77.2)	0.005*	0.01*	0.64
Black Race	7 (8.6)	4 (6.6)	5 (6.3)	0.85	0.65	0.58
Other Race a	14 (17.3)	25 (40.9)	13 (16.5)	0.001*	0.002*	0.89
Hispanic/Latino Ethnicity	3 (3.7)	8 (13.1)	9 (11.4)	0.09	0.049*	0.11
Primary Diagnosis N (%)
Intraparenchymal Hemorrhage	20 (2.5)	11 (18.0)	18 (22.8)	0.63	0.34	0.78
Stroke	19 (23.5)	10 (16.4)	20 (25.3)	0.43	0.30	0.78
Tumor	10 (12.3)	10 (16.4)	15 (19.0)	0.51	0.49	0.25
Traumatic Brain Injury	8 (9.8)	11 (18.0)	9 (11.4)	0.33	0.16	0.76
Aneurysmal SAH	9 (11.1)	5 (8.2)	8 (10.1)	0.89	0.57	0.84
CSVT	0	4 (6.6)	0	0.01*	0.99	0.99
Other b	9 (11.1)	6 (9.8)	6 (7.6)	0.77	0.81	0.45
Injury Location N (%)
Supratentorial	49 (60.5)	49 (80.3)	58 (73.4)	0.03*	0.01*	0.08
Infratentorial	20 (24.6)	6 (9.8)	10 (12.7)	0.04*	0.03*	0.055
Global	4 (4.9)	3 (4.9)	3 (3.8)	0.99	0.99	0.73
Medications N (%)
Pupil Influencing Medications	75 (92.6)	61 (100)	77 (97.5)	0.07	0.99	0.18
Osmotic Medications	35 (43.2)	38 (62.3)	41 (51.9)	0.08	0.03*	0.27
Analgesic Medication	52 (64.1)	55 (90.1)	68 (86.1)	<0.001*	0.001*	0.002*
Sedatives	43 (53.1)	49 (80.3)	48 (60.8)	0.002*	0.001*	0.33
Vasopressors	20 (24.7)	29 (47.5)	15 (18.9)	<0.001*	0.01*	0.38
Antihypertensives	56 (69.1)	52 (85.2)	62 (78.5)	0.07	0.03*	0.18
Stimulants	3 (3.7)	6 (9.8)	3 (3.8)	0.22	0.15	0.98
Anticholinergics	15 (18.5)	23 (37.7)	25 (31.6)	0.03*	0.01*	0.06
Other Medications c	29 (35.8)	35 (57.4)	23 (29.1)	0.003*	0.01*	0.37
Markers of Disease Severity Median [25%,75%]/ N (%)
Midline Shift (mm)	0 [0, 4.0]	4 [0, 8.0]	2 [0, 8.0]	0.02*	0.01*	0.13
Average GCS Over Admission	10 [6.0, 13.0]	7 [5.0, 9.0]	11 [8.0, 14.0]	<0.001*	0.003*	0.01*
Mass Effect	55 (67.9)	49 (80.3)	58 (73.4)	0.32	0.12	0.52
Mechanical Ventilation	60 (74.1)	55 (90.2)	57 (72.2)	0.02*	0.03*	0.68
Intracranial Pressure Monitor	37 (45.7)	32 (52.4)	33 (41.8)	0.48	0.42	0.62
Emergent Surgery d	23 (28.4)	24 (39.3)	23 (29.1)	0.34	0.17	0.92
Uncal Herniation	22 (27.2)	27 (44.3)	21 (26.6)	0.07	0.04*	0.97
Death	32 (39.5)	27 (44.3)	15 (19.0)	0.001*	0.57	0.01*

Univariate analysis of baseline characteristics and NOA status. Global p values were calculated using ANOVA or Fisher Exact Tests. NOA-Abnormal and NOA-Normal specific p values were calculated using logistic/linear regression models with NOA Status as a 3-level factor independent variable with No NOA as the reference level. Abbreviations: SAH = Subarachnoid Hemorrhage, CSVT = Cerebral Sinus Venous Thrombosis, ICP = Intracerebral Pressure.

^aOther Races: Asian (n=9), Native American (n=1), Unspecified (n=44).

^bOther Primary Diagnoses: Isolated IVH (n=1), Isolated hydrocephalus (n=2), Non-aneurysmal SAH (n=1), Epidural Hemorrhage (n=1), Status Epilepticus (n=13), Subdural Hematoma (n=6)

^cOther Medications: Budesonide (n=3), Buspirone (n=13), Cisatracurium (n=19), Dextran (n=11), Digoxin (n=2), Hydroxypropyl (n=1), Latanoprost (n=1), Montelukast (n=3), Naloxone (n=4), Polyvinyl Alcohol (n=17), Racepinephrine (n=1), Rocuronium (n=5), Tamsulosin (n=8), White petrolatum-mineral oil (n=49).

^dEmergent Surgeries: Craniotomy (n=37), Craniectomy (n=45), Subdural hematoma evacuation (n=1), Epidural hematoma evacuation (n=1).